Modeling In Vitro Cellular Responses to Silver Nanoparticles

Figure 2

Cellular interaction, migration, and cytokine secretion of four cell types in the pulmonary alveolar subsystem for a proposed in vivo toxicodynamic model. The diagram includes macrophages, alveolar type I and alveolar type II cells, and immune cells, including cell-cell regulatory and signaling pathways. , , and so forth are the basal kinetic rates of the various cellular processes; is the rate of regulation of process by the cell or chemical in CID . All process and compartment IDs are listed on the right. (The diagram follows the standards of the Systems Biology Graphical Notation (SBGN); see http://www.sbgn.org).