Research Article

Cytotoxicity and Genotoxicity of Panel of Single- and Multiwalled Carbon Nanotubes: In Vitro Effects on Normal Syrian Hamster Embryo and Immortalized V79 Hamster Lung Cells

Table 2

Induction of micronucleated cells after 24 h of treatment with CNTs in V79 and SHE cells.

ChemicalConcentration (μg/cm2)% of cells with MN Mitotic index (%)
V79 cellsSHE cellsV79 cellsSHE cells

Control01.85.16.11.5

MMS0.25 mM18.5*14.1*3.5*2.6*

11000.232,24,94,8 1,8
0.472,25,35,1 1,9
0.942,6*4,55,8 1,7
1.872,7*3,77,5 2,0
3.752,1 4,85,4 1,9

21000.232,6*5,34,4*1,7
0.472,35,65,1 1,9
0.942,7*5,15,0 1,9
1.871,95,34,3*1,4
3.751,94,74,4*1,8

21500.232,6*5,76,4 1,9
0.472,25,94,4*1,9
0.941,64,94,4 1,3
1.872,04,75,0 0,8*
3.751,54,14,7*1,3

DWEF0.232,26,8*5,8 1,5
0.472,7*5,95,0 1,7
0.942,5*5,66,1 1,2
1.872,04,75,5 1,3
3.751,84,76,1 1,1

31000.23 2,9*6,34,7*1,6
0.473,0*6,8*4,6*1,4
0.94 2,46,22,9*2,0
1.87 2,5*5,53,0*1,2
3.75 1,55,43,1*1,2

31500.23 2,6*7,7*4,4 1,4
0.472,07,1*3,0*1,6
0.94 2,9*6,4*3,2*1,3
1.87 2,5*5,83,1*1,2
3.75 3,2*5,93,6*1,2

SBb0.23 3,1*6,6*5,1 1,9
0.473,6*6,7*5,1 0,9*
0.94 4,6*6,5*4,3*0,8*
1.87 5,5*6,4*4,4*0,3*
3.75 5,6*4,43,5*0,2*

SBp0.23 3,8*8,0*6,11,1
0.473,4*6,7*4,6*1,0
0.94 3,8*6,9*4,8 0,8*
1.87 3,7*5,65,0 0,7*
3.75 2,7*3,42,8*0,2*

Data presented were established with at least 3000 cells derived from three independent assays. *Statistically significant ( < 0.05).