Effect of Metformin and Sitagliptin on Doxorubicin-Induced Cardiotoxicity in Rats: Impact of Oxidative Stress, Inflammation, and Apoptosis

Figure 3

Photomicrography of iNOS immunostaining in the studied different animal groups in the third set. (a), (b), and (c) represent minimal expression sections from the control, metformin, and sitagliptin groups, respectively. (d) represents high iNOS expression found in the DOX group. (e) and (f) represent significantly lower iNOS expression found in the metformin/DOX and sitagliptin/DOX groups, respectively, as compared to (d). DAB was used as a chromogen and haematoxylin as nuclear and counter stain. Magnification used is 200x.

(a)

(b)

(c)

(d)

(e)

(f)