Neuroprotective Effects of Alpha-Mangostin on MPP+-Induced Apoptotic Cell Death in Neuroblastoma SH-SY5Y Cells
Effect of alpha-mangostin on Bax, Bcl-2, and p53 mRNA expression in MPP+-treated SH-SY5Y cells. Cells were treated with 10 μM alpha-mangostin (α-M), 1000 μM MPP+, or the combination of α-M and MPP+ for 24 hours. Expression of Bax (a), Bcl-2 (b), Bax/Bcl-2 ratio (c), and p53 mRNA (d) was analyzed with quantitative real-time RT-PCR, relatively compared to their respective untreated controls. The expression levels of the target gene were estimated by the method after normalizing to the expression level of β-actin. Data are expressed as mean ± SEM (). ; .
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