Histopathological Study of Cyclosporine Pulmonary Toxicity in Rats

Figure 2

(a) A photomicrograph of transverse section in the control rat lung shows normal architecture of alveoli (A) with thin interalveolar septa (s) and normal interstitial tissues (I) (H&E ×400). (b) A photomicrograph of transverse section in the second group rat lung shows marked thickening of interstitial tissues (IS) with numerous areas of cellular infiltration (I), congested blood capillaries (bv), and bronchiole (B) with widening alveoli (A) (H&E ×400). (c) A photomicrograph of transverse section in the third group rat lung shows loss of normal architecture, cellular infiltration (I), fragmentation and degeneration of alveoli and interalveolar septum (s) with a subsequent compensatory dilatation of alveoli (A), thickened and congested pulmonary blood vessels (bv), and degenerated bronchiolar wall (B) (H&E ×400).