Histopathological Study of Cyclosporine Pulmonary Toxicity in Rats

Figure 5

(a) Electronic microscopic picture of the control rat lung shows rounded nucleus (N) of pneumocyte type II, lamellar bodies (L) around the nucleus, and mitochondria (m) in cytoplasm with microvilli (Mv) on the surface of alveoli (A) (×10000). (b) Electronicmicroscopic picture of the second group rat lung shows a shrinkage nucleus (N) of pneumocyte type II, vacuoles and congested blood capillaries (C) filled with the blood (b) in the cytoplasm and around the nucleus, degenerated mitochondria (m) in cytoplasm with degenerated microvilli (Mv) on the surface of alveoli (A) (×10000). (c) Electronic microscopic picture of the third group rat lung shows pyknotic nucleus (N) of pneumocyte type II, a variable number of vacuoles (v) and more congested blood capillaries (C) filled with the blood (b) around the nucleus, and degenerated mitochondria (m) in cytoplasm with degenerated microvilli (Mv) on the surface of alveoli (A) (×10000).