Journal of Toxicology / 2016 / Article / Tab 10

Research Article

A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

Table 10

Summary of organ weights relative to body weight (%).

Group (mg/kg bw/d)⁢Organ weight relative to body weight (%)
BrainLiverKidneysHeartThymusSpleenTestes or uterusEpididymides or ovariesAdrenalsThyroids

Males
 Control ()Mean0.5122.3710.5380.2710.1040.1670.8250.3840.0180.007
SD0.0310.2060.0320.0170.0270.0190.0510.0240.0030.001
 180 () Mean0.5192.5510.5640.2690.0960.1830.8310.3910.0180.005
SD0.0210.1370.0340.0370.0180.0110.0600.0310.0030.001
±%185−1−81012−5−19
SS
 300 () Mean0.5402.5020.5930.3050.0820.2030.6920.3470.0220.005
SD0.0540.0990.0450.0310.0110.0210.2010.0460.0030.001
±%561013−2122−16−1018−20
SS
 375 () Mean0.5492.5190.5880.3290.0790.1890.3790.3040.0250.006
SD0.0400.1480.0430.0470.0090.0190.1870.0400.0030.001
±%76922−2313−54−2135−5
SS

Females
 Control ()Mean0.8072.7390.6630.3430.1700.2260.2740.0680.0370.009
SD0.0640.2150.0580.0320.0230.0410.0360.0140.0050.002
 180 () Mean0.8313.0510.6560.3160.1550.2600.3590.0640.0350.009
SD0.0400.1100.0490.0230.0170.0340.1070.0130.0070.002
±%311−1−8−91531−6−47
SS
 300 () Mean0.7942.8280.6250.3670.1320.2440.2330.0590.0370.009
SD0.0540.2040.0250.0310.0190.0290.0780.0120.0050.001
±%−23−67−238−15−1302
SS
 375 () Mean0.7962.8920.6280.3840.1250.2450.2310.0610.0380.009
SD0.0710.2000.0390.0480.0230.0260.0680.0130.0060.002
±%−16−512−278−15−1055
SS

±%, percent deviation versus control, mg/kg bw/d, milligrams per kilogram body weight per day; SD, standard deviation; SS, statistical significance; , number of animals.
< 0.05; < 0.01.