Journal of Toxicology / 2016 / Article / Tab 5

Research Article

A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

Table 5

Summary of food consumption.

Group (mg/kg bw/d)Daily mean food consumption (g/animal/day) on weeks
12345678910111213

Males
 ControlMean25.025.226.426.925.825.926.925.724.225.323.825.424.1
SD1.561.761.931.742.131.942.251.872.042.502.032.312.47
 180Mean23.125.326.627.227.126.826.926.125.326.725.326.226.5
SD1.521.702.131.821.882.162.272.241.881.651.451.591.84
±%−7.70.40.91.15.13.30.11.74.85.96.33.210.2
SS
 300 Mean21.023.623.624.924.524.424.923.923.724.823.724.124.1
SD1.721.432.521.221.161.401.691.471.401.231.471.932.21
±%−16−6−11−7−5−6−7−7−2−20−50
SS
 375Mean18.222.824.424.723.223.224.423.222.623.823.224.624.7
SD2.762.481.621.431.861.711.541.941.862.042.152.762.21
1010101010109999999
±%−27−10−8−8−10−11−9−9−7−6−2−33
SS

Females
 ControlMean17.317.617.818.919.519.319.719.017.919.418.620.520.0
SD1.041.351.191.341.601.371.542.192.212.152.662.312.69
 180 Mean15.517.017.818.218.318.419.317.917.318.817.619.219.4
SD0.530.881.131.101.481.461.511.161.141.631.181.481.69
±%−10−40−4−6−5−2−6−3−3−5−6−3
SS
 300Mean14.616.517.818.418.418.719.518.117.818.818.920.519.6
SD1.811.131.411.121.390.981.611.461.030.682.833.471.18
10101010999998888
±%−15−60−3−6−3−1−50−320−2
SS
 375 Mean14.417.517.618.818.718.619.618.717.718.918.219.819.9
SD1.491.082.141.171.802.261.571.551.451.641.791.911.95
±%−16.9−0.6−1.0−0.5−4.2−3.9−0.3−1.7−1.2−2.9−2.1−3.3−0.2
SS

±%, percent deviation versus control; mg/kg bw/d, milligrams per kilogram body weight per day; SD, standard deviation; g, grams; SS, statistical significance; , number of animals.
< 0.05; < 0.01. unless otherwise stated.