Journal of Toxicology / 2016 / Article / Tab 7

Research Article

A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

Table 7

Summary of statistically significant hematological findings.

⁢Dose group (mg/kg bw/d)
⁢Males⁢Females
Control  
180 
300 
375 
Historical rangeControl 
180 
300  
375 
Historical range

WBC (×109/L)7.91 ± 0.977.69 ± 1.496.69 ± 1.798.13 ± 1.654.60–13.866.20 ± 1.815.63 ± 1.024.74 ± 0.986.57 ± 1.662.96–12.94
MONO (%)2.82 ± 0.483.70 ± 0.852.62 ± 1.172.67 ± 0.680.6–4.12.09 ± 0.642.26 ± 0.312.51 ± 0.451.81 ± 0.480.4–3.1
EOS (%)1.41 ± 0.401.04 ± 0.340.78 ± 0.200.69 ± 0.310.4–3.31.06 ± 0.430.78 ± 0.340.76 ± 0.320.52 ± 0.200.5–2.0
RBC (×1012/L)9.51 ± 0.408.43 ± 0.488.31 ± 0.648.34 ± 0.336.20–10.268.67 ± 0.287.92 ± 0.408.01 ± 0.528.19 ± 0.677.61–9.31
HGB (g/L)168.70 ± 5.93162.00 ± 7.47161.90 ± 10.84163.67 ± 3.50109–184161.20 ± 3.77154.60 ± 6.82158.88 ± 9.49165.20 ± 6.99145–169
MCV (fL)48.04 ± 1.4052.96 ± 2.9653.94 ± 2.1554.17 ± 2.6845.0–53.751.13 ± 2.0954.18 ± 2.7154.78 ± 2.1555.14 ± 1.6547.0–55.0
MCH (pg)17.75 ± 0.4119.24 ± 0.8119.51 ± 0.5719.66 ± 0.8616.7–19.418.61 ± 0.6219.54 ± 0.8919.85 ± 0.5620.25 ± 1.2917.3–19.7
MCHC (g/L)369.70 ± 4.40363.70 ± 9.07361.80 ± 5.92362.89 ± 4.26339–376363.90 ± 5.90360.60 ± 3.53362.75 ± 5.50367.20 ± 17.07351–368
RET (%)3.15 ± 0.303.67 ± 0.324.18 ± 1.723.94 ± 0.562.51–4.653.93 ± 0.494.14 ± 0.793.91 ± 0.634.36 ± 1.223.17–6.16

Values are expressed as mean ± standard deviation. Historical Range based on data from 40 male and 38 female Hsd.Brl.Han Wistar control rats aged 19-20 weeks.
mg/kg bw/d, milligrams per kilogram body weight per day; L, liter; fL, femtoliters; pg, picograms; , number of animals; < 0.05 and < 0.01.