Journal of Toxicology / 2016 / Article / Tab 9

Research Article

A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

Table 9

Summary of organ weights.

Group (mg/kg bw/d)Organ weight (g)
Body weightBrainLiverKidneysHeartThymusSpleenTestes or uterusEpididymides or ovariesAdrenalsThyroids

Males
 Control ()Mean422.02.1610.002.281.140.440.713.491.620.0770.028
SD17.520.160.960.200.090.120.100.340.090.010.01
 180 ()Mean421.82.1910.772.381.140.400.773.511.650.0740.023
SD25.260.120.990.260.190.080.080.340.200.020.01
±%0.01850−8912−4
SS
 300 () Mean393.12.119.832.331.200.320.802.701.360.0850.021
SD28.390.100.770.260.140.060.110.740.150.010.01
±%−7−2−235−2613−23−1610
SS
 375 () Mean377.02.069.512.221.240.300.711.421.140.0930.023
SD26.430.140.990.250.220.050.100.680.120.010.00
±%−11−4−5−39−311−59−3020
SS

Females
 Control ()Mean241.91.946.631.610.830.410.550.660.1650.0880.021
SD15.550.070.700.210.070.060.110.090.0360.0120.003
 180 () Mean242.52.017.411.590.770.380.630.880.1540.0850.022
SD14.740.110.620.140.050.050.100.280.0270.0180.006
±%0412−1−7−81532−7−49
SS
 300 () Mean250.41.987.071.560.920.330.610.580.1480.0920.022
SD15.970.080.560.090.090.050.060.180.0340.0160.004
±%427−311−2011−12−1046
SS
 375 () Mean247.31.967.161.550.950.310.610.570.1510.0950.022
SD21.060.060.840.140.140.070.110.190.0310.0160.005
±%2.20.78.0−3.514.7−25.011.1−13.2−8.36.98.3
SS

±%, percent deviation versus control, mg/kg bw/d, milligrams per kilogram body weight per day; SD, standard deviation; g, grams; SS, statistical significance; , number of animals.
< 0.05; < 0.01.