Chalcone Scaffold in Anticancer Armamentarium: A Molecular Insight

Figure 6

Chalcones against lung cancer and breast cancer cell lines. (12a) IC₅₀ values of 1.35–2.07 μM and (12b) IC₅₀ values of 7.27–11.07 μM: upregulation of the DR5; extrinsic pathway of apoptosis. ((13a) to (13d)) IC₅₀ values ranging from 1.76 to 6.11 μM: inhibited tubulogenesis, caspase-3 and caspase-8 activation, and inhibitory potential against matrix metalloproteinases (MMP-2) secretion. (14) IC₅₀ values of 1.41 and 0.70 μM: cell cycle arrest at G₂/M phase, activation of caspase-3, and cleavage of PARP. (15) IC₅₀ value of less than 0.10 μM: cell cycle arrest at G₂/M phase, activation of caspase-3, and cleavage of PARP. (16) IC₅₀ of 0.8 μM: enhances tubulin polymerization suggesting the activity as microtubule stabilizing agents. (17) IC₅₀ of 0.16 to 0.44 μM and (18) IC₅₀ of 0.56 to 0.65 μM: suppress the activation of NF-κB pathway. (19a) IC₅₀ of 2.25 μM and (19b) IC₅₀ of 3.29 μM: induced DNA fragmentation and apoptosis.