Review Article

Pattern and Epidemiology of Poisoning in the East African Region: A Literature Review

Table 1

Literature review of poisoning in the Eastern Africa subregion.

CountryAuthors (year)Study settingStudy periodType of studyOutcome of interestNumber of cases reviewedMain results

BurundiWHO (2009) [4]National statistics2004Burden of disease estimationMortality from unintentional poisoning7.8 deaths per 100,000 persons
ComorosWHO (2009) [4]National statistics2004Burden of disease estimationMortality from unintentional poisoning1.7 deaths per 100,000 persons
DjiboutiWHO (2009) [4]National statistics2004Burden of disease estimationMortality from unintentional poisoning3.9 deaths per 100,000 persons
DjiboutiBenois et al. (2009) [5]French Military Hospital, Djibouti18 mths, 2006-7Prospective descriptive studyChildhood kerosene poisoning1711 (64.7%) with pulmonary signs, 7 (41%) with pneumonia, and 6 (35%) asymptomatic
DjiboutiSeignot et al. (1992) [6]Hopital d’Instruction des ArmeesCase reportSnakebite (Echis carinatus)1Fatal outcome
DjiboutiLarréché et al. (2011) [7]Intensive care unit of French Military Hospital, in DjiboutiOct 1994–May 2006Retrospective case reviewEffectiveness of delayed antivenom administration in Snakebite with African viperidae7364 (76%) given antivenom; 68 (93%) had coagulopathy; administration of antivenom effective in correcting coagulopathy even if given >24 hours after bite
DjiboutiAigle et al. (2010) [8]July 2008–July 2009Prospective case seriesStingray stings12 stings treated during study period
EritreaWHO (2009) [4]National statistics2004Burden of disease estimationMortality from unintentional poisoning3.7 deaths per 100,000 persons
EthiopiaWHO (2009) [4]National statistics2004Burden of disease estimationMortality from unintentional poisoning3.5 deaths per 100,000 persons
EthiopiaAbebe (1991) [9]Retrospective case reviewOrganophosphate poisoning50Case fatality rate was 20%
94% of cases were attempted suicide
EthiopiaAseffa et al.
(1994) [10]
Gondar College of Medical Sciences Students Clinic31 Dec–4 Jan 1992Prospective case seriesFood poisoning (Salmonella Newport)34479 (23%) of students had clinical symptoms of food poisoning
EthiopiaAlem et al.
(1999) [11]
Butajira rural districtNov 1994–Jan 1995Community based cross-sectional surveySuicide attempts among adults332Poisoning (42.4%) was second most common method of attempting suicide; strong detergents and rodenticides most commonly used by women
EthiopiaAbula and Wondmikun
(2006) [12]
Gondar University Teaching HospitalJul 2001–Jun 2004Retrospective case reviewAcute poisoning102Poisoning accounted for 0.45% of emergency room admissions; organophosphates accounted for 41.5% of poisoning cases; case fatality rate 2.4%
EthiopiaMelaku et al. (2006) [13]Tikur Anbessa Specialised Teaching Hospital1985–2000Retrospective review of admissions to ICUAcute poisoning3548168 (4.7%) admissions and 44 (3.9%) deaths due to organophosphate poisoning
EthiopiaDesalew et al. (2011) [14]Tikur Anbessa Specialised Teaching HospitalJan 2007–Dec 2008Retrospective studyAcute adult poisoning116Most (96.5%) of the cases were intentional self-harm cases with household cleaning agents being the leading toxicants used (43.1%) followed by organophosphates (21.6%); the case fatality rate from this study was reported to be 8.6%
EthiopiaAzazh  (2011) [15]Tikur Anbessa Specialised Teaching HospitalJan 2007Case reportOrganophosphate poisoning1N/A
EthiopiaSelassie
(1998) [16]
Jimma HospitalJan 1996–Jan 1997Prospective study of admissionsOrganophosphate poisoning23Male : female ratio was 1 : 2.83; most common clinical findings were vomiting and abdominal pain; no deaths; average time to reach hospital was 18 hours
EthiopiaMakita et al.
(2012) [17]
Debre Zeyit, EthiopiaN/AMathematical modellingStaphylococcal poisoningN/AAuthors estimated that the annual incidence rate of staphylococcal poisoning in the area was 20 per 1000 people (90% CI: 13.9–26.9)
EthiopiaAga and Geyid (1992) [18]ClinicsJuly-August 1984Datura stramonium688Case fatality rate was 1.31%
KenyaWHO (2009) [4]National statistics2004Burden of disease estimationMortality from unintentional poisoning3.4 deaths per 100,000 persons
KenyaCharters
(1957) [19]
Hospital1949–52Case reportsMushroom poisoning3Clinical signs and symptoms described
KenyaDavidson
(1970) [20]
HospitalCase reportSnakebite (Naja mossambica pallid)1Patient survived
KenyaMwangemi
(1976) [21]
Wajir District HospitalDec 1973–Dec 1975Retrospective case reviewSnakebite38Case fatality rate was 2.6%
KenyaGreenham
(1978) [22]
Garissa Provincial HospitalNov 1976Case reportSnakebite1Clinical picture of snakebite resulting from the spitting cobra (Naja mossambica pallida) in a 5-year-old child
KenyaSmith et al.
(1979) [23]
Gabra nomads?Case seriesBotulism300Attack rate for the entire community of 300 was 3% and 62% for the funeral attenders
Case fatality rate among nomads was 50%
KenyaKahuho
(1980) [24]
Intensive care unit in Kenyatta National HospitalAug 1972–Apr 1978Retrospective case reviewDrug and other chemicals poisoning72Incidence of 33.7 cases per 1000 admissions
Case fatality rate was 36.1% (52% for children under 5 years)
KenyaNgindu et al. (1982) [25]Three hospitals in Machakos district?Case seriesAflatoxicosis2060% case fatality rate
KenyaSnow et al.
(1994) [26]
Kilifi District, Mombasa1994Community based retrospective surveySnakebite4712 householdsAnnual rate of snakebite estimated to be 150 per 100,000 people; only 19% of the victims were bitten by potentially venomous snakes; no deaths
KenyaCoombs et al. (1997) [27](i) Kakamega and western Kenya, (ii) Lake Baringo and Laikipia, (iii) Kilifi and Malindi, and (iv) northern KenyaCommunity based cross-sectional surveySnakebiteThe overall average frequency of snakebite was 13.8 per 100,000 people per year and the minimum rate of snakebite mortality was 0.45/100,000/year
KenyaCDC (2004) [28]Eastern and central provincesApr 2004–Jul 2004Case seriesAflatoxicosis31739.4% case fatality rate
KenyaGuantai et al. (1993) [29]19 Kenyan District and provincial hospitals and Kenyatta National Hospital3 yearsRetrospective case review of paediatric poisoningsPoisoning1904 in total, of which 40% were children <15 yearsIn the under five years group paraffin, drugs, and organophosphates accounted for 41.09, 23.81, and 15.17% of poisoning cases, respectively
KenyaLang et al.
(2008) [30]
Kilifi District HospitalJan 2005–Dec 2006Retrospective case review of paediatric poisoningsAccidental paraffin poisoning48Incidence of children hospitalised with paraffin poisoning was 17 in 100,000
Case fatality rate was 2%
KenyaMusumba et al. (2004) [31]HospitalCase reportSalicylate poisoning3
KenyaMbakaya et al. (1994) [32]Hospital1998/1990Retrospective case reviewPesticide poisoning455455 cases of organochlorine poisoning
KenyaBBC news 20 Nov (2000) [33]Media report2000Methanol poisoning>640 cases512 poisonings, plus 130 deaths from drinking chang’aa; it is also noted that more than 80 people died in 1998
KenyaMinistry Environment (2011) [34]National chemicals profile2005Methanol poisoning50 deaths
KenyaNyamu et al. (2012) [35]Kenyatta National HospitalJan 2002 to June 2003Study of admissionsPoisoning458 casesMost common poisoning was due to pesticides, accounting for 43% of admissions, followed by household products at 24%
MadagascarWHO (2009) [4]National statistics2004Burden of disease estimationMortality from unintentional poisoning2.9 deaths per 100,000 people
MadagascarVicens et al. (1986) [36]Various hospitals1982Laboratory investigation of cases of botulism and analysis of suspected foodFood-induced botulism20Botulinum toxin Type E identified on bioassay
MadagascarDomergue
(1989) [37]
HospitalCase reportsSnakebite (Colubrida opisthoglypha)2
MadagascarHabermehl et al. (1994) [38]Outbreak reportSevere ciguatera/ciguatera-like poisoning>500Case fatality rate was 20%
MadagascarRamialiharisoa et al. (1994) [39]HospitalMar 1991–Jul 1992ObservationalSpider bite (latrodectism)10Case fatality rate was 10%
MadagascarRamialiharisoa et al. (1996) [40]; Ramialiharisoa et al. (1997) [41]VohipenoOutbreak reportCiguatera/ciguatera-like poisoning600310 patients admitted, 4 deaths
MadagascarRanaivoson et al. (1994) [42]Dec 1994Outbreak reportSeafood (sea turtle) poisoning60The poisoning attack rate was 48%
The case fatality rate was 7.7%
MadagascarBoisier et al. (1994) [43]HospitalProspective observationalSeafood (Carcharhinus leucas) poisoning200The poisoning attack rate was 100%
The case fatality rate was 30%
MadagascarChampetier De Ribes et al. (1998) [44]National surveillanceJan 1993–Jan 1998Prospective epidemiological studySeafood poisoning19 episodes1789 people poisoned; 70% of episodes were due to consumption of sea turtle or shark; there were 102 deaths (case fatality rate of 6%)
MadagascarRibes et al.
(1999) [45]
560 villages with 585,000 people along the Madagascar coast1996-1997Community based knowledge, attitude, and practice (KAP) surveySeafood poisoning380 cases of poisoning recalled over 1930–1996Sharks were responsible for most serious poisoning (48%), in addition to other fishes (37%) and marine turtles (11%); neurological and gastrointestinal features predominated in shark poisonings
MadagascarRobinson et al.
(1999) [46]
Tulear Province with 41 villages spread along 300 km of coast with about 34,000 inhabitantsJun-July 1996Community based KAP surveySeafood poisoning84Cases reported over period 1931–1995, involving fish, sharks, and turtles; case fatality rate of 16.7%
MadagascarRavaonindrina et al. (2001) [47]July 1998Case seriesPuffer fish poisoning4One death; tetrodotoxin identified.
MalawiWHO (2009) [4]National statistics2004Burden of disease estimationMortality from unintentional poisoning0.9 deaths per 100,000 persons
MalawiO’Reilly and Heikens (2011) [48]HospitalCase reportOrganophosphate poisoning1Survived
MalawiChibwana et al. (2001) [49]Queen Elizabeth Central Hospital1 yearProspective observationalChildhood poisoning144Most (82%) of admissions were due to accidental poisoning
Case fatality rate was 7.6%
MalawiDzamalala et al. (2006) [50]Queen Elizabeth Central Hospital and University of Malawi College of Medicine MortuariesJan 2000–Dec 2003Retrospective audit of suicides autopsiedDeliberate self-harm leading to death (suicides)84Pesticide poisoning accounted for 66 cases (79%) of suicide
MalawiYu et al. (2009) [51]Central referral hospital?Retrospective case reviewChildhood injuryPoisoning accounted for 15.1% of child injuries in the study
MauritiusWHO (2009) [4]National statistics2004Burden of disease estimationMortality from unintentional poisoning0.1 deaths per 100,000 persons
MauritiusGlaizal et al.
(2011) [52]
?March 2010Case reportsCiguatera/ciguatera-like poisoning4Clinical poisoning, with recurrence 1 year later
MozambiqueWHO (2009) [4]National statistics2004Burden of disease estimationMortality from unintentional poisoning3.4 deaths per 100,000 persons
MozambiqueMinistry of Health (1984) [53]Nampula provinceAug–OctCommunity based cross-sectional surveySpastic paraparesis (mantakassa/konzo) caused by cassava consumption1102Highest incidence rate was 34 per 1000 inhabitants in one village
MozambiqueCliff et al. (1986) [54]Acordos de Lusaka village, Memba District1981?Konzo caused by cassava consumption?Incidence rate was 34 cases per 1000 people
MozambiqueCasadei et al. (1990) [55]Acordos de Lusaka village, Memba District1982?Spastic paraparesis caused by cassava consumption?Incidence rate was 4 cases per 1000 persons
MozambiqueCliff and Coutinho
(1995) [56]
Provincial Hospital in ChimoioJun–Aug 1992Case seriesAcute cassava intoxication700.14% case fatality rate
74% children under 15 years; 17% women and 9% men
MozambiqueCliff et al. (1997) [57]In Mujocjo, Nacacana, Moconi, and Terreni A Chieftaincies in Mogincual district, MozambiqueJuly 1993Community based cross-sectional surveySpastic paraparesis caused by cassava consumption72The highest prevalence rate was 30/1000 in Mujocojo Chieftaincy
MozambiqueCliff et al.
(1999) [58]
Mogincual districtJuly 1993Ankle clonus, thiocyanate, linamarin and sulphate excretion397Proportion of children with clonus ranged from 4% to 22%; geometric mean thiocyanate, linamarin, and inorganic sulphate concentrations were 163 and 60 mol/L and 4.4 mmol/L, respectively
MozambiqueErnesto et al. (2002) [59]Memba and Mogincual districts: 3 communitiesOct 1999Community based surveyKonzo and cyanogen in flour27Proportion of schoolchildren with ankle clonus was 8% to 17%; 27 new cases of konzo were found; cassava flour samples were found to contain 26 to 186 ppm of cyanogen.
RwandaWHO (2009) [4]National statistics2004Burden of disease estimationMortality from unintentional poisoning1.3 deaths per 100,000 persons
SeychellesWHO (2009) [4]National statistics2004Burden of disease estimationMortality from unintentional poisoning0 deaths per 100,000 persons
SeychellesLagraulet (1975) [60]Case reportPoisoning with fish toxin
SeychellesMyers et al. (2009) [61]Seychelles Child Development StudyProspective longitudinal studyEffects of methyl mercury exposure779Recent postnatal exposure at 107 months of age was adversely associated with four endpoints, but no consistent pattern
UgandaWHO (2009) [4]National statistics2004Burden of disease estimationMortality from unintentional poisoning11.4 deaths per 100,000 persons
UgandaBwibo (1969) [62]New Mulago HospitalJan 1963–Dec 1968Retrospective case reviewAccidental poisoning in children130Admission rate for accidental poisoning in children was 0.65%
Case fatality rate was 5.4%; household chemicals accounted for largest number of poisonings
UgandaCardozo and Mugerwa (1972) [63]Mulago Hospital, KampalaJan–Dec 1970Retrospective hospital based case reviewAcute poisoning7048 cases were children, accounting for 0.75% of total paediatric admissions for the period; most admissions were for kerosene ingestion
22 cases were adults, accounting for 0.35% of the total admissions; pesticide poisoning was the most common cause
UgandaKinyanda et al. (2004) [64]KampalaNov 2001–Oct 2002Case-control studyDeliberate self-harm (DSH)100 cases of DSH; 300 controlsPoisoning was the most important method used in DSH (65%).
Organophosphates accounted for the highest proportion (45%) with medications accounting for (35%)
UgandaMalangu
(2008) [65]
Two Hospitals in KampalaJan–June 2005Retrospective hospital based case reviewAcute poisoning276Agrochemicals (42.4%) were responsible for most of the admitted cases that presented for treatment, followed by household chemicals (22.1%), carbon monoxide (20%), snakebites (14.1%), and food poisoning (1.4%)
The overall case fatality rate was 1.4%, due to alcohol, carbon monoxide, and organophosphates
UgandaOffice of the President (2009) [66]Nationwide2009Press releaseMethanol poisoning2719 deaths
UgandaDigital Journal (2010) [67]Southwest Uganda2010Media reportMethanol poisoning18989 deaths
United Republic of TanzaniaWHO (2009) [4]National statistics2004Burden of disease estimationMortality from unintentional poisoning6.6 deaths per 100,000 persons
United Republic of TanzaniaRwiza (1991) [68]Usangi Government HospitalJun 1981Hospital based case seriesDatura stramonium food contamination10No fatalities recorded
United Republic of TanzaniaYates et al.
(2010) [69]
Snake Park Clinic, MeseraniApr 2007–Dec 2009Clinic based prospective case seriesManagement of snakebites8542 cases received antivenom; the case fatality rate was 1% (1 death in a 12-year-old), while 7% had a skin graft or amputation of a limb or digit
United Republic of TanzaniaMbakaya et al. 1994 [32]Hospitals1989/1990Retrospective case reviewPesticide poisoning736736 cases of organochlorine poisoning during study period
United Republic of TanzaniaHowlett et al. (1990, 1992) [70, 71]Tarime District1985Case reviewKonzo associated with cassava consumption118 cases including 2 verified deaths
United Republic of TanzaniaMlingi et al. (1991) [72]Msasi District1988Case reviewKonzo associated with cassava consumption3
United Republic of TanzaniaMlingi et al. (2011) [73]Mbinga District
Mtwara Region
2001/2002 & 2002/2003Konzo associated with cassava consumption24 cases (Mbinga)
214 cases (Mtwara)
United Republic of TanzaniaNdosi et al. (2004) [74]Muhimbili Hospital, Dar Es SalaamProspective study of suicidesPoisoning100 suicides69% used poisoning, predominantly using antimalarials and pesticides
ZambiaWHO (2009) [4]National statistics2004Burden of disease estimationMortality from unintentional poisoning4.8 deaths per 100,000 persons
ZambiaGill (1979) [75]Hospitals in Chingola and ChililabombweDec 1975–Jan 1978Case seriesMushroom poisoning14The case fatality rate 14%
ZambiaBhushan et al.
(1979) [76]
University Teaching Hospital, Lusaka1978Retrospective hospital based case reviewAccidental poisoning378Case fatality rate of 0.5% with paraffin poisoning accounting for the largest proportion of admissions (57.1%), food poisoning (18.3%), household poisons (11%), and medicines (10.8%)
ZambiaGernaat et al. (1998) [77]St. Paul’s Hospital, Nchelenge4 yearsCombined retrospective and prospective study of admissionsPoisoning6412Main prevalence of snakebite was in ages of 4–14 yrs
ZambiaSinclair et al. (1989) [78]Hospital16 monthsCase series of nontraumatic comaPoisoning170Organophosphate poisoning, a significant cause
ZimbabweWHO (2009) [4]National statistics2004Burden of disease estimationMortality from unintentional poisoning8 deaths per 100,000 people
ZimbabweNhachi and Kasilo  (1992) [79]Six referral hospitals in Zimbabwe1980–1989Retrospective hospital case reviewAdmitted cases of poisoning6018Case fatality rate was 15%
ZimbabweTagwireyi et al. (2002) [80]Eight referral hospitals in ZimbabweJan 1998–Dec 1999Retrospective hospital case reviewAdmitted cases of poisoning2764Case fatality rate was 4.4% for all cases
ZimbabweTagwireyi et al. (2006) [81]Six district hospitals and one provincial hospitalJan 1998–Dec 1999Retrospective hospital case reviewAdmitted cases of poisoning711 district hospital cases and 341 provincial casesCase fatality rate was 4.8% (district hospitals) and 4.7% (provincial hospital)
ZimbabweDong and Simon
(2001) [82]
Parirenyatwa hospitalJan 1995–Nov 2000Retrospective hospital case reviewOrganophosphate poisoning599Most cases were due to deliberate self-poisoning (74%)
The case fatality rate was 8.3%
Admissions increased by 320% over the 6 years
ZimbabweKasilo et al.
(1991) [83]
Six referral hospitals1980–1989Retrospective hospital case reviewOrganophosphate poisoning606Most cases were due to deliberate self-poisoning (75%)
The case fatality rate in the series was 8%
ZimbabweNhachi (1988) [84]One referral hospital and one district hospitalJan 1981–Dec 1986Retrospective hospital case reviewOrganophosphate poisoning161 (urban); 11 (rural)Most cases (83%) were intentional poisoning from urban and for rural centre most (70%) were accidental
Case fatality rate 14% (urban)
ZimbabweNyazema (1984) [85]Two central hospitals and Government Analyst Laboratory1971–1982Retrospective case reviewNumber of cases of traditional medicine poisoning?297 cases admitted to Harare hospital for the period from 1971 to 1982
ZimbabweKasilo and Nhachi (1992) [86, 87]Six referral hospitals1980–1989Retrospective hospital case reviewTraditional medicines poisoning1456Case fatality rate was 6%
ZimbabweTagwireyi and Ball
(2002) [88]
Parirenyatwa Central HospitalJan 1995–Dec 1999Retrospective hospital case reviewTraditional medicines poisoning in adults16No deaths reported
ZimbabweTagwireyi et al. (2002) [89]Eight referral hospitals in ZimbabweJan 1998–Dec 1999Retrospective hospital case reviewTraditional medicines poisoning in adults63Case fatality rate was 9.5%
ZimbabweTagwireyi and Ball (2002) [88]Parirenyatwa Central HospitalJan 1995–Dec 1999Retrospective hospital case reviewElephant’s Ear poisoning15Clinical presentation and management of Elephant’s Ear poisoning was described
No deaths were reported
ZimbabweFlegg (1981) [90]Mar 1980–Mar 1981Retrospective hospital case reviewMushroom poisoning50Case fatality rate was 12%
ZimbabweTagwireyi et al. (2002) [91]Eight referral hospitals in ZimbabweJan 1998–Dec 1999Retrospective hospital case reviewAcute poisoning in children (0–12 yrs)76197.5% admissions due to accidental poisoning
Household chemicals especially paraffin responsible for largest proportion of admissions (43.2%)
Case fatality rate was 3.1%
ZimbabweChitsike (1994) [92]Intensive care unit, Parirenyatwa Hospital1990-1991Retrospective hospital case reviewSevere acute poisoning in children42Household chemicals especially paraffin responsible for largest proportion of admissions (26.2%)
Case fatality rate of 21%
ZimbabweKasilo and Nhachi (1992) [86, 87]Six referral hospitals1980–1989Retrospective hospital case reviewAcute poisoning in children (0–15 yrs)2873Most cases accidental (93.4%)
Household chemicals especially paraffin responsible for largest proportion of admissions (27.2%)
The case fatality rate of 4.9%
ZimbabweBlaylock (1982) [93]Triangle District HospitalJan 1975–Jun 1981Retrospective hospital case reviewSnakebite250Case fatality rate of 0.4%
ZimbabweGeddes and Thomas (1985) [94]?Case reportSnakebite1Patient survived
ZimbabweKasilo and Nhachi (1993) [95, 96]Six referral hospitals1980–1989Retrospective hospital case reviewSnakebite995Case fatality rate was 1.8%
ZimbabweMuguti et al.
(1994) [97]
Mpilo Central HospitalJan 1990–Jun 1992Retrospective hospital case reviewSnakebite83Case fatality rate was 5%
ZimbabweNhachi and Kasilo (1994) [98, 99]Jan 1991–Dec 1992ProspectiveSnakebite poisoning274Case fatality rate was 1.8%
ZimbabweMuguti and Dube (1998) [100]Mpilo Central Hospital?Case reportSnakebite from the vine snake (Thelotornis capensis oatessi)1Patient survived
ZimbabweTagwireyi et al. (2004, 2011) [101, 102]Eight referral hospitalsJan 1998–Dec 1999Retrospective hospital case reviewSnakebite273Case fatality rate was 2.9%
ZimbabweNhachi and Kasilo (1994) [98, 99]Six referral hospitals1980–1989Retrospective hospital case reviewHousehold chemical poisoning1192Majority of the cases (61.3%) occurred in the 0–5 years age group
Case fatality rate of 13%
ZimbabweTagwireyi et al. (2006) [103]Eight referral hospitalsJan 1998–Dec 1999Retrospective hospital case reviewParaffin (Kerosene) poisoning327Most exposure instances (91.7%) occurred accidentally, with only 6.7% resulting from deliberate ingestion of the chemical
The case fatality rate was 0.3%
ZimbabweBergman (1997) [104, 105]Rural clinics in Gwanda South DistrictSep 1991–Sep 1993Prospective hospital and clinic based surveyParabuthus transvaalicus scorpionismCase fatality rate was 0.3%; the mortality rate in the district was 2.8 per 100 000 per year
ZimbabweSaunders and Morar (1990) [106]Case reportScorpion sting1Patient survived without any specific scorpion antivenin administration
ZimbabweNhachi and Kasilo (1993) [107]Six referral hospitals1980–1989Retrospective hospital case reviewScorpion and insects poisoning92In scorpion sting/bite admissions, bees (44.6%), wasps (8.7%), and spiders (8,7%) accounted for most of the exposure instances
No fatalities were recorded
ZimbabweTagwireyi and Ball (2011) [108]Eight referral hospitals1998-1999Retrospective hospital case reviewScorpion envenomation29No fatalities
ZimbabweKasilo and Nhachi (1994) [109]Six referral hospitals1980–1989Retrospective hospital case reviewFood poisoning487Case fatality rate was 2.5%
ZimbabweTagwireyi et al. (2000) [110]A provincial hospital1999Case reportCantharidin poisoning due to blister beetle ingestion1Patient survived
ZimbabweNhachi et al. (1992) [111]Six referral hospitals1980–1989Retrospective hospital case reviewTherapeutic drugs poisoning1061Pharmaceutical poisoning admissions resulted from mainly accidental exposure (63.5%)
The case fatality rate was 3.9%
ZimbabweQueen et al.
(1999) [112]
May 1987–April 1995Retrospective hospital case reviewChloroquine overdose?Preponderance of females taking chloroquine in overdose, compared to other overdoses and toxic exposure, was reported (OR 1.99; 95% CI 1.31–3.04; )
Case fatality rate of 40%
ZimbabweMcKenzie (1996) [113]Nov 1990–Oct 1994Retrospective hospital case reviewChloroquine overdose29Case fatality rate of 20.7%
ZimbabweBall et al. (2002) [114]Eight referral hospitalsJan 1998–Dec 1999Retrospective hospital case reviewChloroquine poisoning544 (chloroquine 279)Case fatality rate due to chloroquine poisoning significantly higher than that of poisoning due to other drugs (5.7% versus 0.7%; )
ZimbabweTagwireyi et al. (2006) [81]Six referral hospitals and one provincial hospitalJan 1998–Dec 1999Retrospective hospital case reviewDifferences and similarities in poisoning admissions in urban and rural health centres711 (district hospital); 341 (provincial hospital)Case fatality rate for district hospitals was 4.8%
Case fatality rate for provincial hospital was 4.7%
ZimbabweTagwireyi et al. (2006) [115]Eight referral hospitalsJan 1998–Dec 1999Retrospective hospital case reviewPesticide poisoning914Almost half (49.1%) resulted from oral exposure to rodenticides, 42.2% from anticholinesterase-type pesticides (AChTP)
The case fatality rate was 6.8%
ZimbabweKasilo and Nhachi (1993) [96]Six referral hospitals1980–1989Retrospective hospital case reviewMetal poisoning40Copper accounted for the largest proportion (27.5%)