Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in Rats

Table 2

Effect of DLD (25 mg/kg/day) and DHD (50 mg/kg/day) on GSH, catalase, and SOD in DOX (15 mg/kg) induced nephrotoxicity.

Group	GSH (mmol/g tissue)	Catalase (unit/g tissue)	SOD (unit/g tissue)
Control	10.32 ± 0.2999	92.10 ± 2.835	829.7 ± 5.182
DLD	10.22 ± 0.5530	91.53 ± 1.860	832.0 ± 6.915
DHD	9.085 ± 0.3000	91.80 ± 2.127	826.6 ± 7.575
DOX	4.814 ± 0.1630^a	72.49 ± 3.662^a	657.6 ± 15.28^a
DOX/DLD	8.678 ± 0.1985^ab	80.48 ± 4.108	722.7 ± 41.13^a
DOX/DHD	9.215 ± 0.2814^b	8627 ± 4.496^b	807.3 ± 16.96^b

Values are representation of 4–6 observations as means ± SEM. Results are considered significantly different when . Significant difference compared to control; significant difference compared to DOX group.