Evaluation of “Dream Herb,” Calea zacatechichi, for Nephrotoxicity Using Human Kidney Proximal Tubule Cells

Figure 2

C. zacatechichi significantly decreases cell viability in a dose-dependent manner. HK-2 cells were treated with C. zacatechichi (open circles), cisplatin (open squares), or valproic acid (filled circles) at mean average concentrations (± SEM) ranging from 0 to 1000 μg/mL and cell viability was quantitatively assayed by ATP luminescence 24 hours after treatment. Dashed line indicates “no treatment” baseline ATP levels. , cisplatin or valproic acid versus C. zacatechichi, .