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Journal of Toxicology
Volume 2017 (2017), Article ID 1907952, 5 pages
https://doi.org/10.1155/2017/1907952
Review Article

Hepatocyte CYP2B6 Can Be Expressed in Cell Culture Systems by Exerting Physiological Levels of Shear: Implications for ADME Testing

1Durham VA Medical Center, Research & Development Service, Durham, NC 27705, USA
2Nephrology Division, Department of Internal Medicine, Duke University School of Medicine, Durham, NC 27705, USA
3Space Policy Institute, Elliott School of International Affairs, George Washington University, Washington, DC 20052, USA
4Department of Veterans Affairs Office of Research and Development, Washington, DC 20420, USA
5Departments of Otorhinolaryngology, Immunology, and Psychiatry, Baylor College of Medicine, Houston, TX 77030, USA

Correspondence should be addressed to Timothy G. Hammond; moc.oohay@eciffofotuodnommah and Holly H. Birdsall; moc.liamg@llasdribhh

Received 24 June 2017; Revised 27 July 2017; Accepted 7 August 2017; Published 10 September 2017

Academic Editor: Lucio Guido Costa

Copyright © 2017 Timothy G. Hammond and Holly H. Birdsall. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

How to Cite this Article

Timothy G. Hammond and Holly H. Birdsall, “Hepatocyte CYP2B6 Can Be Expressed in Cell Culture Systems by Exerting Physiological Levels of Shear: Implications for ADME Testing,” Journal of Toxicology, vol. 2017, Article ID 1907952, 5 pages, 2017. doi:10.1155/2017/1907952