Association of Paraoxonase-1 Q192R (rs662) Single Nucleotide Variation with Cardiovascular Risk in Coffee Harvesters of Central Colombia

Table 4

Markers of organophosphate exposure and CVD risk according to the PON1 Q192R genotype.

Allele	Q 248 (60)		R 162 (40)		Dominant model			Recessive model
Genotype	QQ; 79 (38)	QR; 90 (44)	RR; 36 (18)
Parameters	QQ	QR	RR	p	QQ	QR + RR	p	QQ + QR	RR	p
Butyrylcholinesteras (μkat/L)				0.559			0.406			0.736
HDL cholestero (mg/dL)				0.931			0.898			0.776
Total cholestero (mg/dL)				0.166			0.452			0.180
Total cholestero
Normal	24 (31)	40 (52)	13 (17)	0.166	24 (31)	53 (69)	0.093	64 (83)	13 (17)	0.843
Hypercholesterolemia	55 (43)	50 (39)	23 (18)		55 (43)	73 (57)		105 (82)	23 (18)
					1.664 0.917–3.019]			0.927 0.439–1.959]
Blood pressur
Normal	46 (34)	61 (44)	30 (22)		46 (34)	91 (66)		107 (78)	30 (22)
Hypertension	33 (48)	29 (43)	6 (9)		33 (48)	35 (52)		62 (91)	6 (9)
					1.865 1.031–3.376]			2.897 1.142–7.348]
10-year ASCVD ris
Low	58 (37)	66 (43)	31 (20)	0.271	58 (37)	97 (63)	0.563	124 (80)	31 (20)	0.106
High	21 (42)	24 (48)	5 (10)		21 (42)	29 (58)		45 (90)	5 (10)
					1.211 0.633–2.318]			2.250 0.824–6.142]

Data are expressed as (%), mean ± SD, and odds ratio [95% CI]. values were obtained by -way ANOVA and -square test. significant ().