Journal of Toxicology / 2017 / Article / Tab 4

Research Article

Association of Paraoxonase-1 Q192R (rs662) Single Nucleotide Variation with Cardiovascular Risk in Coffee Harvesters of Central Colombia

Table 4

Markers of organophosphate exposure and CVD risk according to the PON1 Q192R genotype.

AlleleQ 248 (60)R 162 (40)Dominant modelRecessive model
GenotypeQQ
79 (38)
QR
90 (44)
RR
36 (18)
ParametersQQQRRRpQQQR + RRpQQ + QRRRp

Butyrylcholinesteras (μkat/L)0.5590.4060.736

HDL cholestero (mg/dL)0.9310.8980.776

Total cholestero (mg/dL)0.1660.4520.180

Total cholestero
 Normal24 (31)40 (52)13 (17)0.16624 (31)53 (69)0.09364 (83)13 (17)0.843
 Hypercholesterolemia55 (43)50 (39)23 (18)55 (43)73 (57)105 (82)23 (18)
1.664 0.917–3.019]0.927 0.439–1.959]

Blood pressur
 Normal46 (34)61 (44)30 (22)46 (34)91 (66)107 (78)30 (22)
 Hypertension33 (48)29 (43)6 (9)33 (48)35 (52)62 (91)6 (9)
1.865 1.031–3.376]2.897 1.142–7.348]

10-year ASCVD ris
 Low58 (37)66 (43)31 (20)0.27158 (37)97 (63)0.563124 (80)31 (20)0.106
 High21 (42)24 (48)5 (10)21 (42)29 (58)45 (90)5 (10)
1.211 0.633–2.318]2.250 0.824–6.142]

Data are expressed as (%), mean ± SD, and odds ratio [95% CI]. values were obtained by -way ANOVA and -square test. significant ().