Long-Term Safety of PEGylated Coagulation Factor VIII in the Immune-Deficient Rowett Nude Rat

Table 6

Anti-N8-GP antibodies detected in animals during the dosing phase.

Group	Dose (IU/kg/fourth day)	Anti-N8-GP antibodies (positive/total)
		26-week study (week 26)	52-week study (week 26)	52-week study (week 52)
2	50	2/36	3/42	2/36
3	150	1/34	1/40	0/35
4	500	2/35	0/38	1/34
5	1200	0/34	2/39	1/35