Tramadol Induced Adrenal Insufficiency: Histological, Immunohistochemical, Ultrastructural, and Biochemical Genetic Experimental Study

Figure 1

Photomicrographs of the adrenal gland of the control group showing (a) adrenal cortex (C), zona glomerulosa (ZG), zona fasciculata (ZF), zona reticularis (ZR), and adrenal medulla (M) ×100. (b) A higher magnification of ZG cells arranged in oval or rounded clusters and with deeply stained nuclei (arrow), ×400. (c) A higher magnification of ZF cells showing highly vacuolated cells (black arrow) and less vacuolated cells with acidophilic cytoplasm (yellow arrow) and vesicular nuclei, ×400. (d) A higher magnification of ZR showing small cells with deeply acidophilic cytoplasm (arrow); M, medulla, ×400.