Tramadol Induced Adrenal Insufficiency: Histological, Immunohistochemical, Ultrastructural, and Biochemical Genetic Experimental Study

Figure 2

Photomicrographs of the adrenal gland of group II showing (A) loss of normal architecture of ZG and ZF, ×100; (B) higher magnification of ZG and ZF showing some cells with marked vacuolated cytoplasm (black arrow) and pyknotic nuclei; others are shrunken (yellow arrow) with pyknotic nuclei and deeply acidophilic cytoplasm; notice the congested blood capillaries (c), ×400; (C) ZR with markedly congested blood capillaries (c), ×100.