Tramadol Induced Adrenal Insufficiency: Histological, Immunohistochemical, Ultrastructural, and Biochemical Genetic Experimental Study

Figure 8

Electron micrographs of the adrenal cortex in group II showing that ZG cells with (a) nuclei (N) have irregular outlines and few lipid droplets (L). Notice the shrunken nucleus (n) with widened perinuclear space (arrow in inset). Notice the fibroblast of the capsule with elongated nucleus (fn). (b) Degenerated mitochondria with disrupted cristae (M) and dilated cisternae of SER (s).

(a)

(b)