Synergistic Effect of Quercetin and α-Lipoic Acid on Aluminium Chloride Induced Neurotoxicity in Rats

Table 2

Effect of aluminum chloride, quercetin, and α-lipoic acid (ALA) treatment on various antioxidant defence indices in the brain of rats.

Experimental groups	Reduced glutathione	Glutathione reductase	Superoxide dismutase	Catalase
Control	0.268 ± 0.024	0.062 ± 0.003	1.33 ± 0.14	2.68 ± 0.30
Aluminum chloride	0.135 ± 0.011	0.035 ± 0.004	0.90 ± 0.07	5.52 ± 0.34
Quercetin	0.243 ± 0.015	0.065 ± 0.005	1.47 ± 0.11	2.28 ± 0.25
Quercetin + aluminum chloride	0.223 ± 0.017	0.052 ± 0.001	1.36 ± 0.05	2.68 ± 0.20
α-Lipoic acid	0.258 ± 0.019	0.063 ± 0.004	1.41 ± 0.03	1.97 ± 0.09
α-Lipoic acid + aluminum chloride	0.223 ± 0.015	0.056 ± 0.004	1.28 ± 0.04	1.96 ± 0.16
Quercetin + α-lipoic acid	0.290 ± 0.014	0.062 ± 0.004	1.74 ± 0.19	2.59 ± 0.26
Quercetin + α-lipoic acid + aluminum chloride	0.247 ± 0.014	0.052 ± 0.001	1.58 ± 0.05	2.22 ± 0.22

Significant as compared to control group of rats (). Significant as compared to control group of rats (). Significant as compared to control group of rats (). Significant as compared to AlCl₃ treated group of rats (). Nonsignificant as compared to control (). Comparison between the groups was done using Dunnett’s multiple comparison test; values are expressed as ±mg of reduced glutathione mg protein⁻¹; values are expressed as ±millimoles of glutathione reduced min⁻¹mg protein⁻¹; values are expressed as ±units mg protein⁻¹. One unit of enzyme was defined as the amount of enzyme which inhibited formazone formation by 50%; values are expressed as ± μmole of H₂O₂ dissipated min⁻¹mg protein⁻¹.