Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberration in Onion Root Cells

Table 7

Mean values of chromosome aberrations observed in the micronucleus test after exposure of A. cepa root tip cells to DHAP.

Concentration of DHAP (μg/ml)	24h											44h
	S	C-M	Br	M	F	BN	MCN	AC	TC	DC	CA (%)	S	C-M	Br	M	F	B	MCN	AC	TCC	DC	CA (%)
Control	0	0	0	0	0	0	0	0	563	31.6	0.00	0	0	0	0	0	0.2	0	0.2	516	28.6	0.69
0.25	0	0	0.4	0	0.2	0	0	0.6	623	33.2	1.8	0	0	0.2	0	0.6	0.0	0	0.8	598	25.2	3.1
0.5	0	0	0.2	0	1.0	0.6	0.2	2.0	616	20.0	10.	0	0	0.6	0	1.0	0.6	0	2.2	645	19.2	11.
1	0	0	1.0	0	0.6	0.6	0	2.2	619	18.6	9.	0	0	0	0	0.6	0.8	0	1.4	597	11.8	11.
Mean	0	0	0.4	0	0.4	0.3	0.05	1.2	605	25.9	5.35	0	0	0.2	0	0.6	0.4	0	1.2	589	21.2	6.80
SD	0	0	0.43	0	0.41	0.35	0.1	1.1	28.3	7.61	5.18	0	0	0.3	0	0.4	0.36	0	0.9	53.6	7.73	5.73

Note: sticky (S), C-mitosis (CM), bridge (Br), fragment (F), binuclei (BN), micronuclei (MCN), aberrant cells (AC), total cells counted (TCC), dividing cells (DC), chromosome aberration (CA), hour (h), and standard deviation (SD). CA (%) marked with asterisks are significantly different from the negative control (= p<0.05; = p<0.01;= p<0.001).