Table of Contents Author Guidelines Submit a Manuscript
Journal of Toxicology
Volume 2018 (2018), Article ID 5243617, 16 pages
https://doi.org/10.1155/2018/5243617
Research Article

A Toxicological Evaluation of a Standardized Hydrogenated Extract of Curcumin (CuroWhite™)

1Liveon Biolabs (P) Ltd., Tumkur, Karnataka 572106, India
2R&D Centre, Aurea Biolabs (P) Ltd., Kolenchery, Cochin, Kerala 682311, India

Correspondence should be addressed to Sreeraj Gopi; moc.sdipiltnalp@ipog.jareers and Tumkur Subbarao Jagannath; moc.sbaloibnoevil@htannagaj

Received 12 October 2017; Accepted 19 December 2017; Published 23 January 2018

Academic Editor: Syed Ali

Copyright © 2018 Alastimmanahalli Narasimhiah Ravikumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A series of toxicological investigations were conducted in order to evaluate the genotoxic potential and repeated-dose oral toxicity of CuroWhite, a proprietary extract of curcumin that has been hydrogenated and standardized to not less than 25% hydrogenated curcuminoid content. All tests were conducted in general accordance with internationally accepted standards. The test item was not mutagenic in the bacterial reverse mutation test or in vitro mammalian chromosomal aberration test, and no in vivo genotoxic activity was observed in rat bone marrow in the micronucleus test. A 90-day repeated-dose study was conducted in male and female Sprague-Dawley rats. Two mortalities occurred in the main and satellite high-dose groups and were determined due to gavage error. No organ specific or other toxic effects of the test item were observed up to the maximum dose of 800 mg/kg bw/day, administered by gavage. NOAEL was, therefore, estimated as 800 mg/kg bw/day.