A Toxicological Evaluation of a Standardized Hydrogenated Extract of Curcumin (CuroWhite™)
Table 3
Summary of the results of Method I (plate incorporation test).
Test concentration (/plate)
Number of revertants/plate (mean of 3 plates)
Without S9
With S9
TA 98
TA 100
WP2 uvrA
TA 1537
TA 1535
TA 98
TA 100
WP2 uvrA
TA 1535
TA 1537
Historical negative control range
20–50
45–200
10–50
5–20
5–20
20–50
45–200
10–50
5–20
5–20
Solvent control (DMSO) (0.1 ml)
Mean
25
79
17
10
11
21
69
15
10
7
SD
3
7
1
2
1
4
4
5
2
2
0.062 mg
Mean
27
70
16
9
9
23
78
18
9
7
SD
4
10
4
2
2
4
6
3
2
2
0.185 mg
Mean
24
79
20
10
9
22
75
22
5
9
SD
4
5
2
2
1
7
1
2
2
2
0.556 mg
Mean
26
81
25
8
9
25
79
21
8
11
SD
3
5
4
3
3
2
3
2
2
2
1.667 mg
Mean
29
91
27
12
11
25
83
24
6
10
SD
3
4
3
1
3
3
8
2
3
2
2.5 mg
Mean
28
84
28
11
10
22
81
28
8
7
SD
3
2
2
2
3
4
6
2
2
3
3.75 mg
Mean
30
94
33
13
12
30
79
24
12
8
SD
4
8
2
2
4
3
10
3
1
3
5 mg
Mean
34
98
30
12
15
29
85
26
9
11
SD
2
1
6
4
2
1
6
4
2
3
2-Nitrofluorene
Sodium azide
4-Nitroquinoline
9-Aminoacridine
Sodium azide
2-Aminoanthracene
Positive controls
Mean
414
465
168
181
193
371
442
160
165
173
SD
19
19
22
16
25
17
30
25
9
24
DMSO: dimethylsulfoxide; SD: standard deviation; TA: Salmonella Typhimurium tester strains; WP2 uvrA: Escherichia coli tester strain. Notes. All values are expressed as mean revertant colonies per plate ± standard deviation.
