A Toxicological Evaluation of a Standardized Hydrogenated Extract of Curcumin (CuroWhite™)
Table 7
Summary results of the micronucleus test.
Groups ()
Mean P/E ratio
Mean PCE analyzed
MPCE
Mean #
Mean%
SD
Males
Vehicle-control
0.54
2093.8
19.8
0.95
±0.08
Cyclophosphamide (50 mg/kg bw)
0.52
2041.4
134.6
6.60
±0.76
200 mg/kg bw
0.55
2015.0
20.4
1.01
±0.05
400 mg/kg bw
0.53
2028.4
20.0
0.99
±0.11
800 mg/kg bw
0.56
2023.2
21.8
1.08
±0.07
Females
Vehicle-control
0.54
2021.8
26.6
1.32
±0.65
Cyclophosphamide (50 mg/kg bw)
0.50
2017.0
129.6
6.43
±0.38
200 mg/kg bw
0.51
2014.6
20.2
1.00
±0.13
400 mg/kg bw
0.50
2021.6
22.8
1.13
±0.11
800 mg/kg bw
0.49
2011.0
24.6
1.22
±0.16
MPCE: micronucleated polychromatic erythrocytes; P/E: polychromatic erythrocytes/total erythrocytes; PCE: polychromatic erythrocytes; SD: standard deviation. Symbols. .Notes. All values are expressed as means (% MPCE expressed as mean ± SD). Statistical analysis using one-way ANOVA followed by Dunnett’s posttest, as compared to vehicle-control.
