A Toxicological Evaluation of a Standardized Hydrogenated Extract of Curcumin (CuroWhite™)

Table 8

Summary of statistically significant clinical chemistry parameters.

Group; (mg/kg bw/day)	TPROT; (g/dL)	Glucose; (mg/dL)	ALT; (IU/L)	TG; (mg/dL)	Urea; (mg/dL)	CREA; (mg/dL)	Na^+; (mmol/L)
Main groups, male
G1 (vehicle-control)	6.99 ± 0.68	66.38 ± 15.68	52.16 ± 12.56	62.38 ± 15.37	38.43 ± 8.11	0.79 ± 0.18	140.56 ± 6.16
G2 (200)	6.59 ± 0.50	65.31 ± 8.68	52.16 ± 10.32	56.29 ± 15.14	46.38  ±  9.03	0.64  ±  0.09	144.54 ± 5.83
G3 (400)	6.51 ± 0.77	94.39  ±  37.90	48.44 ± 6.63	40.75  ±  12.19	51.78  ±  5.31	0.64  ±  0.10	148.68  ±  5.85
G4 (800)	7.04 ± 0.65	85.37 ± 12.00	49.50 ± 15.18	57.67 ± 17.32	42.76 ± 2.40	0.60  ±  0.13	144.50 ± 5.27
Recovery groups, male
G1R (vehicle-control)	8.65 ± 0.64	76.41 ± 14.62	50.92 ± 6.30	82.15 ± 10.62	46.24 ± 7.67	0.16 ± 0.05	155.04 ± 28.97
G4R (800)	8.49 ± 1.20	70.55 ± 8.57	65.06  ±  5.06	73.77 ± 27.87	53.96 ± 11.60	0.17 ± 0.03	124.56 ± 13.84
Main groups, female
G1 (vehicle-control)	6.45 ± 1.22	68.00 ± 16.75	42.26 ± 6.48	55.35 ± 20.03	50.70 ± 6.90	0.75 ± 0.14	143.31 ± 10.40
G2 (200)	6.86 ± 0.78	68.91 ± 19.32	50.56 ± 9.94	52.66 ± 23.03	49.27 ± 6.61	0.69 ± 0.14	146.79 ± 6.17
G3 (400)	7.09 ± 1.00	59.61 ± 16.43	46.85 ± 10.68	37.27  ±  5.06	49.46 ± 7.14	0.64 ± 0.08	147.37 ± 9.87
G4 (800)	6.44 ± 0.37	65.16 ± 16.32	51.27 ± 8.04	41.17 ± 7.37	44.65 ± 5.62	0.60  ±  0.09	145.26 ± 7.69
Recovery groups, female
G1R (vehicle-control)	8.44 ± 0.25	115.90 ± 20.89	40.67 ± 6.00	70.59 ± 23.91	53.89 ± 11.02	0.79 ± 0.20	192.54 ± 59.07
G4R (800)	7.93  ±  0.27	119.10 ± 34.09	47.74 ± 4.33	59.63 ± 42.00	42.21 ± 4.47	0.81 ± 0.08	143.50 ± 27.56

ALT: alanine aminotransferase; CREA: creatinine; Na⁺: sodium; TG: triglycerides; TPROT: total protein. Symbols.  ; ; ; in the G4 male group; in the G4R female group. Notes. All values are expressed as mean ± SD. Statistical analysis of main groups using one-way ANOVA followed by Dunnett’s posttest as compared to vehicle-control. Statistical analysis of recovery groups using Student’s -test as compared to vehicle-control.