Alpha Mangostin Inhibits the Proliferation and Activation of Acetaldehyde Induced Hepatic Stellate Cells through TGF- and ERK 1/2 Pathways

Figure 3

Effect of alpha mangostin in HSC proliferation as shown by (a) percentage of cell viability over control. (b) mRNA expressions of Ki67/β-actin expressions, after LX-2 cells were treated with alpha mangostin with or without acetaldehyde induction. Results were presented as mean ± SEM. A: p<0.05 versus untreated group, B: p<0.05 versus acetaldehyde group. Veh: vehicle only, Acet: acetaldehyde 100 μM, Acet+ SF10: acetaldehyde 100 μM + sorafenib 10 μM, Acet + AM10: acetaldehyde 100 μM + alpha mangostin 10 μM, Acet + AM20: acetaldehyde 100 μM + alpha mangostin 20 μM, AM 10: alpha mangostin 10 μM.

(a)

(b)