Alpha Mangostin Inhibits the Proliferation and Activation of Acetaldehyde Induced Hepatic Stellate Cells through TGF- and ERK 1/2 Pathways

Figure 5

Effect of alpha mangostin on profibrogenic markers as shown by mRNA expressions of (a) Col1A1/β-actin, (b) TIMP1/β-actin, and (c) TIMP2/β-actin, after LX-2 cells were treated with alpha mangostin with or without acetaldehyde induction. Results were presented as mean ± SEM. A: p<0.05 versus untreated group, B: p<0.05 versus acetaldehyde group. Veh: vehicle only, Acet: acetaldehyde 100 μM, Acet + SF10: acetaldehyde 100 μM + sorafenib 10 μM, Acet + AM10: acetaldehyde 100 μM + alpha mangostin 10 μM, Acet + AM20: acetaldehyde 100 μM + alpha mangostin 20 μM, AM 10: alpha mangostin 10 μM.

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