Alpha Mangostin Inhibits the Proliferation and Activation of Acetaldehyde Induced Hepatic Stellate Cells through TGF- and ERK 1/2 Pathways

Figure 6

Effect of alpha mangostin on HSCs migration markers as shown by mRNA expressions of (a) MMP2/β-actin and (b) MMP9/β-actin, after LX-2 cells were treated with alpha mangostin with or without acetaldehyde induction. Results were presented as mean ± SEM. A: p<0.05 versus untreated group, B: p<0.05 versus acetaldehyde group. Veh: vehicle only, Acet: acetaldehyde 100 μM, Acet + SF10: acetaldehyde 100 μM + sorafenib 10 μM, Acet + AM10: acetaldehyde 100 μM + alpha mangostin 10 μM, Acet + AM20: acetaldehyde 100 μM + alpha mangostin 20 μM, AM 10: alpha mangostin 10 μM.

(a)

(b)