In Vivo and In Vitro Toxicity Evaluation of Hydroethanolic Extract of Kalanchoe brasiliensis (Crassulaceae) Leaves
Table 1
Results of the biochemical dosages in the evaluation of acute toxicity of K. brasiliensis.
Parameters/groups
Control
250 mg/kg
500 mg/kg
1000 mg/kg
Males
Glucose (mg/dl)
102,30 ± 95,39
202,00 ± 75,16
215,80 ± 56,44
190,60 ± 67,77
Triglycerides (mg/dl)
94,11 ± 41,97
81,20 ± 20,85
78,20 ± 14,57
73,20 ± 14,24
Cholesterol (mg/dl)
111,89 ± 26,54
202,60 ± 64,10
114,40 ± 45,77
116,40 ± 15,34
TP (mg/dl)
4,19 ± 0,85
2,16 ± 1,69
5,08 ± 1,57
4,64 ± 0,83
AST (U/L)
131,22 ± 56,82
148,60 ± 31,11
148,00 ± 18,55
152,40 ± 56,29
ALT (U/L)
56,70 ± 15,88
55,40 ± 13,22
70,80 ± 7,60
46,80 ± 15,47
Urea (mg/dl)
72,56 ± 6,06
82,20 ± 12,26
70,60 ± 8,08
76,00 ± 6,96
Creatinine (mg/dl)
0,13 ± 0,20
0,48 ± 0,33
0,24 ± 0,22
0,40 ± 0,00
Females
Glucose (mg/dl)
144,20 ± 50,25
226,20 ± 53,27
126,80 ± 41,14
234,60 ± 38,60
Triglycerides (mg/dl)
114,40 ± 31,09
144,60 ± 44,50
81,40 ± 18,15
72,00 ± 8,19
Cholesterol (mg/dl)
124,40 ± 11,67
106,60 ± 19,19
75,00 ± 14,88
102,20 ± 10,85
TP (mg/dl)
2,92 ± 0,85
5,46 ± 0,55
3,76 ± 0,91
3,64 ± 0,46
AST (U/L)
151,80 ± 82,79
201,60 ± 195,69
127,40 ± 6,88
147,20 ± 57,84
ALT (U/L)
70,40 ± 2,07
53,00 ± 14,76
72,20 ± 5,76
38,20 ± 12,05
Urea (mg/dl)
73,60 ± 2,07
59,00 ± 7,91
53,20 ± 7,79
54,80 ± 11,88
Creatinine (mg/dl)
0,16 ± 0,22
0,42 ± 0,04
0,24 ± 0,22
0,22 ± 0,16
Values are expressed as mean ± standard deviation (). AST: aspartate aminotransferase; ALT: alanine aminotransferase; TP: total protein. presenting statistical difference with the control group ().
