An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin
Table 1
Mutagenicity assay: mean revertant frequency in the absence of metabolic activation system.
Concentrations (g/plate)
TA1537
TA1535
TA98
TA100
TA102
Mean ± SD
#
Mean ± SD
#
Mean ± SD
#
Mean ± SD
#
Mean ± SD
#
Vehicle Control (0.0)
10.00 ± 3.61
NA
14.00 ± 1.00
NA
25.33 ± 1.53
NA
100.33 ± 14.01
NA
344.00 ± 14.42
NA
5.0
10.67 ± 0.58
1.07
20.00 ± 13.00
1.43
23.00 ± 6.24
0.91
104.00 ± 7.94
1.04
377.33 ± 26.63
1.10
16.0
9.67 ± 4.62
0.97
13.00 ± 4.36
0.93
21.00 ± 1.00
0.83
115.00 ± 3.00
1.15
370.67 ± 27.23
1.08
50.0
14.67 ± 3.06
1.47
10.67 ± 1.15
0.76
24.00 ± 5.29
0.95
118.00 ± 13.23
1.18
365.33 ± 43.14
1.06
160.0
11.67 ± 0.58
1.17
12.67 ± 3.06
0.91
23.67 ± 2.31
0.93
111.00 ± 10.15
1.11
305.33 ± 65.77
0.89
500.0
11.33 ± 4.04
1.13
12.67 ± 2.52
0.91
27.67 ± 4.73
1.09
98.00 ± 15.87
0.98
266.67 ± 24.44
0.78
1600.0
11.33 ± 3.06
1.13
11.67 ± 4.51
0.83
32.67 ± 16.86
1.42
96.00 ± 7.94
0.92
274.00 ± 57.65
0.80
9AA (50.0)
1043.33 ± 51.32
104.33
-
-
-
-
-
-
-
2NF (25.0)
-
-
-
-
1260.00 ± 65.57
49.74
-
-
-
-
SA (20.0)
-
-
1110.00 ± 105.36
79.29
-
-
1410.00 ± 36.06
14.05
-
-
Ametycin (0.25)
-
-
-
-
-
-
-
-
1626.67 ± 211.97
4.73
9AA, 9-aminoacridine; NA, not applicable; 2NF, 2-nitrofluorene; MMC, mitomycin C; SA, sodium azide; SD, standard deviation; VC, vehicle control; #, relative fold values as compared to VC. Note. Vehicle is dimethyl sulfoxide; 9AA, 2NF, SA, and ametycine are positive controls.
