Organs/Histopathology lesions / no. of tissues examined Vehicle 0 250 500 1000 ref item 1000 Males Kidneys Basophilic tubules 0/20 - - - - 1/20 1/20 Lungs Infiltration, foamy macrophages, alveolar 8/20 7/20 11/20 4/20 11/20 Inflammatory foci, chronic 4/20 1/20 1/20 0/20 0/20 Inflammation chronic and fibrosis, interstitial 0/20 1/20 7/20 3/20 11/20 Granuloma, foreign body 0/20 1/20 5/20 1/20 11/20 Osseous metaplasia 2/20 0/20 0/20 0/20 1/20 Stomach Erosion, mucosa, glandular, focal 1/20 - - - - 0/20 1/20 Spleen Increased extramedullary hematopoiesis 0/20 - - - - 1/20 1/20 Thymus Hyperplasia, epithelial 2/20 - - - - 0/20 1/20 Testes Atrophy/ degeneration, seminiferous tubules, unilateral/ bilateral 2/20 - - - - 1/20 0/20 Epididymides Vacuolation, epithelial 2/20 - - - - 1/20 1/20 Sperm granuloma 2/20 - - - - 2/20 1/20 Oligospermia 2/20 - - - - 1/20 0/20 Prostate Infiltration, mononuclear cells, interstitial 1/20 - - - - 1/20 2/20 Females Liver Vacuolation, cytoplasmic, periportal 0/20 - - - - 1/20 2/20 Lungs Infiltration, foamy macrophages, alveolar 12/20 11/20 10/20 11/20 6/20 Inflammatory foci, chronic 1/20 4/20 1/20 0/20 2/20 Inflammation chronic and fibrosis, interstitial 0/20 4/20 1/20 8/20 4/20 Granuloma, foreign body 0/20 3/20 1/20 2/20 3/20 Infiltration, polymorphonuclear cells, alveolar 0/20 2/20 0/20 2/20 0/20 Osseous metaplasia 1/20 0/20 1/20 0/20 0/20 Ovaries Cyst, luteal 1/20 - - - - 1/20 0/20 Uterus with cervix and vagina Increased mucification, epithelium, cervix and vagina 0/20 - - - - 1/20 1/20 Urinary bladder Infiltration, mononuclear cells, submucosa 0/20 - - - - 1/20 1/20