An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin
Table 2
Mutagenicity assay: mean revertant frequency in the presence of metabolic activation system (5% v/v, S9).
Concentration (g/plate)
TA1537
TA1535
TA98
TA100
TA102
Mean ± SD
#
Mean ± SD
#
Mean ± SD
#
Mean ± SD
#
Mean ± SD
#
Vehicle Control 0.0
13.33 ± 0.58
NA
14.00 ± 3.61
NA
32.00 ± 9.54
NA
107.67 ± 5.13
NA
289.33 ± 64.38
NA
5.0
13.67 ± 5.13
1.03
12.00 ± 1.00
0.86
22.00 ± 4.36
0.69
107.00 ± 6.56
0.99
302.00 ± 20.88
1.04
16.0
15.00 ± 0.00
1.13
11.67 ± 2.52
0.83
28.67 ± 6.81
0.90
114.67 ± 4.51
1.07
340.67 ± 37.22
1.18
50.0
14.00 ± 1.00
1.05
11.67 ± 2.89
0.83
23.67 ± 2.52
0.74
116.00 ± 35.09
1.08
362.67 ± 25.17
1.25
160.0
13.67 ± 2.08
1.03
13.33 ± 2.08
0.95
23.00 ± 4.36
0.72
121.00 ± 9.64
1.12
280.67 ± 33.49
0.97
500.0
11.67 ± 3.79
0.88
11.33 ± 1.53
0.81
24.00 ± 5.57
0.75
88.33 ± 6.66
0.82
353.33 ± 30.55
1.22
1600.0
11.00 ± 1.73
0.83
10.00 ± 3.00
0.71
36.33 ± 17.62
1.65
101.67 ± 22.19
0.95
322.67 ± 44.06
1.12
2AA (20.0)
1026.67 ± 140.12
77.02
1036.67 ± 130.51
74.05
1180.00 ± 60.00
36.88
1533.33 ± 135.03
14.24
1740.00 ± 87.18
6.01
2AA, 2-aminoanthracene; NA, not applicable; SD, standard deviation; #, relative fold values as compared to Vehicle Control. Note. Vehicle is dimethyl sulfoxide; 2AA is the positive control.
