An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin

Table 7

Mean body weights for the 90-day study on curcumin.

Group	Day / Body Weight (g)
n=20; mg/kg; bw/day		1	8	15	22	29	36	43	50	57	64	71	78	85	90
	Males
Vehicle	Mean	174.28	212.83	243.56	271.50	299.19	318.98	337.42	351.65	364.72	376.89	384.98	392.33	397.09	400.54
0	SD	11.51	17.19	20.13	22.94	25.01	24.35	29.40	31.89	33.48	34.64	35.06	35.57	36.63	37.18
250	Mean	177.16	214.00	246.07	271.88	296.26	315.99	333.32	344.86	355.03	365.52	371.93	376.73	381.17	383.93
	SD	13.74	13.18	14.32	16.72	20.18	22.36	25.21	26.03	26.39	29.27	31.54	32.90	33.00	34.52
500	Mean	178.57	217.82	254.98	286.03	313.89	335.72	356.92	369.90	382.61	393.92	401.14	406.57	415.12	417.18
	SD	13.42	13.70	14.47	14.65	17.14	18.84	21.18	23.29	25.48	27.46	28.50	28.04	29.20	29.09
1000	Mean	173.03	213.96	246.54	272.97	301.45	323.37	340.95	352.78	366.35	376.83	382.72	389.27	397.12	400.97
	SD	12.08	12.73	12.13	14.37	16.96	19.66	22.28	24.26	27.01	26.05	24.46	25.49	25.65	26.01
Ref Item	Mean	171.34	209.30	240.81	265.27	291.83	309.92	326.03	339.20	350.40	361.16	367.49	374.05	378.81	383.67
1000	SD	13.75	18.47	20.28	22.27	24.62	25.15	25.43	26.11	27.44	30.72	31.23	31.68	34.20	33.83
	Females
Vehicle	Mean	142.22	162.16	177.00	187.93	199.51	206.83	214.65	219.22	223.98	227.10	229.34	232.61	234.13	234.84
0	SD	12.84	12.25	14.21	14.82	14.53	14.68	15.43	15.23	16.27	16.33	15.79	16.18	16.85	16.48
250	Mean	141.57	163.45	180.25	191.80	200.57	208.29	217.53	219.72	222.27	225.41	229.64	230.38	232.30	232.85
	SD	10.72	10.58	11.89	11.89	12.42	11.83	11.68	12.18	13.51	13.39	13.79	14.63	15.35	15.15
500	Mean	142.24	161.19	177.56	187.87	199.22	204.19	212.63	215.23	221.07	223.30	226.21	227.48	229.99	231.08
	SD	10.61	10.44	12.33	12.66	13.83	14.22	14.66	14.63	15.63	15.81	16.82	16.71	17.05	17.21
1000	Mean	142.48	161.92	175.93	187.59	202.90	212.25	218.30	222.86	228.31	231.99	233.25	237.91	239.97	241.14
	SD	11.95	12.56	16.62	15.34	16.10	16.75	18.76	18.99	19.42	19.02	19.97	20.60	21.60	21.89
Ref	Mean	142.97	161.96	175.80	188.52	201.32	208.54	214.51	219.45	223.55	227.50	230.28	233.14	234.30	235.08
Item 1000	SD	13.34	14.44	14.04	15.83	17.70	18.16	18.35	19.42	20.53	20.19	18.94	18.22	19.05	18.82

n, number of animals per group; SD, standard deviation.