An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin
Table 8
Summary of feed consumption for the 90-day study on curcumin.
Group
Feed Consumption (g) /day/animal
n=20 mg/kg bw/day
Days
1 - 2
8-9
15-16
22-23
29-30
36-37
43-44
50-51
57-58
64-65
71-72
78-79
85-86
89-90
Males
Vehicle
Mean
20.55
21.86
21.96
21.89
23.15
22.40
21.58
21.49
21.07
21.46
21.89
22.36
22.60
21.17
0
SD
2.25
1.47
2.55
2.07
3.46
1.43
1.45
1.37
1.48
1.59
1.51
1.09
1.64
0.68
250
Mean
19.92
22.19
21.57
21.03
23.97
21.28
21.67
19.56-
22.19
21.30
20.42
21.03
21.20
20.88
SD
1.92
1.45
1.52
1.20
3.49
1.32
1.39
1.01
0.65
1.35
1.50
1.08
1.13
0.95
500
Mean
40.80+
23.70
22.80
21.50
26.28+
22.37
22.33
21.05
21.99
21.75
21.30
21.18
21.63
21.14
SD
2.52
2.42
1.28
0.96
4.32
1.04
0.85
0.91
0.96
1.67
1.00
1.71
1.37
0.70
1000
Mean
19.99
23.71+ ↑
22.68
23.24↑
24.06↑
23.47↑
22.72↑
21.64
20.22
21.35↑
21.59↑
21.58
22.48
21.13
SD
1.17
2.44
1.24
1.26
3.36
1.33
1.44
1.13
1.37
1.55
1.25
1.06
1.28
1.23
Ref Item
Mean
17.30-
21.27
21.54
21.51
20.76
21.16
20.19
21.34
19.77
19.83
19.91-
20.80-
21.27
21.85
1000
SD
3.80
1.96
1.82
1.42
1.56
1.37
1.17
2.06
1.75
1.39
1.74
1.12
1.60
0.76
Females
Vehicle
Mean
15.07
15.04
16.23
16.18
16.66
17.89
14.65
16.82
16.42
17.08
16.23
16.08
14.81
16.59
0
SD
2.54
1.08
1.28
1.30
1.18
0.55
0.79
1.31
1.02
0.94
0.79
0.66
0.44
1.53
250
Mean
15.51
13.92
16.71
16.45
17.75
14.62-
15.75+
17.10
15.51
16.28
15.23
16.58
15.36
15.92
SD
1.29
1.15
1.07
1.72
1.40
1.64
0.97
1.81
2.02
1.96
2.18
1.13
1.75
1.27
500
Mean
12.76-
14.03
15.85
15.98
16.46
16.32-
15.17
17.44
14.43-
15.38-
16.03
16.26
14.75
15.26
SD
1.05
1.77
1.47
1.77
1.45
1.92
1.75
0.46
1.11
1.46
1.57
1.08
1.03
1.23
1000
Mean
15.46
15.11
16.31
16.61
16.92
18.80
16.21+
17.18
16.45
17.19
16.81
16.54
16.45+
16.31
SD
1.30
1.85
2.08
1.90
1.81
1.17
1.08
1.37
0.71
0.76
0.98
1.28
1.93
1.33
Ref Item
Mean
15.75
15.51
15.47
16.64
17.17
18.49
16.02
16.12
17.31
16.76
16.37
16.31
16.01
16.22
1000
SD
2.26
2.00
2.97
2.64
2.60
2.43
2.94
0.64
2.39
1.23
1.13
1.19
2.34
1.33
n= number of animals, = statistically significant increase/decrease as compared to vehicle control (p<0.05), = statistically significant increase/decrease as compared to vehicle control (p<0.01), and ↑/↓ = statistically significant increase/decrease as compared to the reference item group (p<0.05); Ref, reference.
