An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin

Table 9

Summary of significant Hematology measures in the 90-day study on curcumin.

Group		RBC	HGB	MCV	MCH	MCHC	RDW	Retic	MPV	WBC	Neu	Lymp	Mono	Mono	Plt
n=20; mg/kg; bw/day		(10^6 cells/µL)	(g/dL)	(fL)	(pg)	(g/dL)	(%)	(x10^9 cells/L)	(fL)	(10^3 cells/µL)	(10^3 cells/ µL)	(10^3 cells/µL)	(10^3 cells/µL)	(%)	(x10^3 cells/µL)
Males
Vehicle	Mean	9.12	15.65	54.02	17.17	31.80	12.55	110.20	9.01	7.07	1.74	5.00	0.17	2.42	856.95
0	SD	0.26	0.41	1.74	0.70	0.56	0.63	20.54	0.37	1.39	0.78	1.02	0.08	0.71	114.07
250	Mean	8.84-	15.50	55.18	17.55	31.81	12.95+	116.79	8.76	6.35	1.40	4.67	0.13-	1.94-	831.50
	SD	0.33	0.49	1.28	0.49	0.71	0.35	16.55	0.61	1.15	0.50	0.93	0.05	0.56	113.52
500	Mean	8.76-	15.43-	56.37+	17.63	31.27	13.05+	104.27	8.76	5.37-	1.22-	3.91-	0.12-	2.42	853.30
	SD	0.71	1.22	2.15	0.78	0.58	0.58	32.83	0.21	1.12	0.44	0.79	0.09	2.23	87.57
1000	Mean	8.67-	15.43	55.57+	17.84	32.09	12.57	111.90	9.56+	6.10-↑	1.19-	4.65↑↑	0.10-	1.60-↓	812.55
	SD	0.47	0.39	2.40	0.80	0.54	0.57	21.42	0.55	1.20	0.42	0.96	0.03	0.30	91.69
Ref Item	Mean	8.75-	15.71+	55.69	17.97+	32.26	12.65	98.60	9.34+	5.35-	1.18-	3.93-	0.10-	1.87-	816.00
1000	SD	0.40	0.52	1.90	0.69	0.62	0.34	25.64	0.38	0.76	0.37	0.68	0.03	0.42	107.22
Historical Range		7.67–9.45	13.00–16.00	46.00–54.80	14.30–17.90	30.60–34.60	11.90–14.30	40.70–164.30	6.7–11.6	3.72–10.81	0.84–2.94	2.45–8.85	0.07–0.27	1.30–2.70	650–1058
Females
0	Mean	8.15	14.92	57.17	18.30	32.04	11.56	116.71	7.63	4.96	1.20	3.53	0.11	2.05	855.65
	SD	0.29	0.56	1.75	0.62	0.48	0.44	27.68	0.43	1.99	0.92	1.09	0.08	0.81	91.24
250	Mean	8.09	15.39+	57.94	19.04+	32.86+	11.13	145.26	8.59+	5.11	1.02	3.84	0.10	1.94	870.45
	SD	0.29	0.52	1.76	0.59	0.49	0.39	35.77	0.63	1.05	0.39	0.95	0.03	0.39	103.34
500	Mean	8.11	15.08	56.63	18.61	32.84+	11.25	116.62	8.62+	3.58-	0.68-	2.73-	0.06-	1.67	886.75
	SD	0.29	0.31	1.31	0.46	0.68	0.46	27.41	0.46	0.89	0.24	0.68	0.02	0.49	88.98
1000	Mean	8.22	15.13	57.17	18.44	32.26	11.38	98.44↓	7.47	4.29	0.97	3.11	0.08	1.98	893.45
	SD	0.35	0.49	1.55	0.59	0.65	0.44	28.90	0.35	1.11	0.36	1.00	0.03	0.59	109.44
Ref item	Mean	8.01	14.92	57.36	18.65	32.51	11.56	117.96	7.41	4.54	1.05	3.24	0.09	1.90	863.10
1000	SD	0.31	0.48	2.11	0.73	0.78	0.59	31.28	0.61	1.08	0.43	0.90	0.04	0.65	90.93
Historical Range		6.64–8.87	12.00–15.20	49.70–58.20	16.10–18.60	31.10–35.40	10.60–14.30	72.40–221.30	6.5–11.5	3.14–10.03	0.60–2.24	1.24–7.07	0.05–0.25	1.10–3.60	560–1047

Key: n= No. of animals, = Statistically significant increase/decrease as compared to vehicle control (p<0.05), = Statistically significant increase/decrease as compared to vehicle control (p<0.01), ↑/↓= Statistically significant increase/decrease as compared to the reference item group (p<0.05), ↑↑ = Statistically significant increase as compared to the reference item group (p<0.01); Ref, reference.
Abbreviations: HGB, hemoglobin; Lymp, lymphocytes; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; MCV, mean corpuscular volume; Mono, monocytes; MPV, mean platelet volume; Neu, neutrophils; Plt, platelets; RBC, red blood cells; RDW, red cell distribution width; Retic, reticulocytes; WBC, white blood cells.