Ameliorating Iron Overload in Intestinal Tissue of Adult Male Rats: Quercetin vs Deferoxamine

Figure 2

Representative photographs of the histologic sections of ileal tissues obtained from the studied groups. A: The ileal parts from control group show normal histological architecture, while villi appear widely separated villi (V) and lined by columnar cell with basal oval nuclei (CE), numerous goblet cells (g) and lamina propria (LP) with abundant cellular elements can be seen. B: The ileal tissues of ironoverload group show eroded villi with epithelial lining loss, numerous goblet cells (g), areas with single columnar layer (CE), and areas with stratified epithelial lining (SE) and intraepithelial lymphocytes (thin arrow) are observed. Lamina propria (LP) with giant iron laden cell (thick arrow) are clarified. Luminal iron (Li) in crystalline and linear forms is observed. C: The ileal tissues of iron + DFO treated group show an eroded villus (EV). Villi with areas with single columnar layer (CE) are areas with stratified epithelial lining (SE) are seen. Lamina propria (LP), intraepithelial lymphocytes (arrow) and iron deposit in epithelium or lamina propria (arrow head) are observed. D: ileal tissues of iron+ Quercetin-treated group show villi with numerous goblet cells (g), while single columnar layer (CE) and lamina propria (LP) are clarified. (H&E × 400).