Table 10: Summary of selected† hematological findings in the 90-day repeated oral toxicity study.

GroupNEULYMMONOEOSRBCHGBHCTMCVMCHMCHCPLTRETAPTT
(mg/kg bw/day)%%%%×1012/Lg/LL/LfLpgg/L×109/L%sec

Male (main groups, = 10 each)
Control14.21 ± 2.4482.56 ± 2.642.20 ± 0.400.99 ± 0.319.46 ± 0.28167.60 ± 4.990.46 ± 0.0149.06 ± 1.5217.71 ± 0.43361.00 ± 4.24787.30 ± 90.203.01 ± 0.4421.73 ± 3.64
10019.25 ± 3.80∗∗77.81 ± 4.172.13 ± 0.380.77 ± 0.299.49 ± 0.54166.70 ± 6.730.46 ± 0.0248.97 ± 1.9217.59 ± 0.59359.50 ± 5.15804.00 ± 93.503.26 ± 0.3322.67 ± 1.59
36016.40 ± 4.5081.30 ± 4.881.85 ± 0.460.44 ± 0.20∗∗9.72 ± 0.47168.80 ± 6.990.47 ± 0.0247.96 ± 1.4717.39 ± 0.45362.30 ± 5.19848.80 ± 79.823.03 ± 0.2725.48 ± 4.32
72018.03 ± 3.9879.70 ± 4.191.84 ± 0.570.42 ± 0.25∗∗9.41 ± 0.55158.30 ± 6.85∗∗0.44 ± 0.02∗∗46.75 ± 2.2516.86 ± 0.59∗∗360.60 ± 6.17845.10 ± 58.723.17 ± 0.3522.45 ± 2.56
Historical range9.7–38.756.5–87.81.8–5.10.3–9.07.52–10.21141–1800.404–0.48945.4–53.716.6–18.8349–379595–9572.05–4.6515.2–31.8

Male (recovery groups, = 5 each)
Control15.42 ± 4.7780.12 ± 5.803.06 ± 0.821.34 ± 0.499.90 ± 0.56171.60 ± 5.860.47 ± 0.0247.34 ± 2.4017.34 ± 0.77367.00 ± 4.64831.00 ± 91.483.39 ± 0.2019.80 ± 3.67
72020.94 ± 6.6875.74 ± 6.452.20 ± 0.661.08 ± 0.339.66 ± 0.44167.00 ± 7.910.46 ± 0.0347.56 ± 2.0417.28 ± 0.38363.80 ± 8.47758.00 ± 125.593.62 ± 0.2821.02 ± 1.82

Female (main groups, = 10 each)
Control11.49 ± 4.3085.13 ± 4.832.06 ± 0.591.30 ± 0.548.49 ± 0.39159.80 ± 2.860.45 ± 0.0152.88 ± 2.9018.87 ± 0.83356.90 ± 5.47753.80 ± 94.293.95 ± 0.6821.01 ± 2.26
10018.80 ± 5.14∗∗78.45 ± 5.32∗∗1.93 ± 0.500.82 ± 0.538.77 ± 0.25159.70 ± 5.010.45 ± 0.0250.84 ± 1.7518.20 ± 0.46358.30 ± 5.52788.60 ± 63.523.70 ± 0.6923.73 ± 4.91
36013.99 ± 2.8583.81 ± 3.081.60 ± 0.440.60 ± 0.22∗∗8.89 ± 0.37156.90 ± 5.320.44 ± 0.0149.54 ± 2.02∗∗17.66 ± 0.67∗∗356.50 ± 3.31835.10 ± 73.323.35 ± 0.4521.49 ± 2.74
72014.06 ± 3.2883.65 ± 3.531.47 ± 0.370.80 ± 0.408.99 ± 0.25∗∗155.30 ± 4.720.43 ± 0.0148.26 ± 0.75∗∗17.28 ± 0.29∗∗358.00 ± 5.03757.50 ± 63.893.06 ± 0.47∗∗20.87 ± 3.40
Historical range5.8–33.363.4–91.11.1–3.90.4–2.17.71–9.17148–1680.415–0.46747.0–60.117.2–20.8346–372549–11032.77–5.6317.4–27.9

Female (recovery groups, = 5 each)
Control19.62 ± 6.9677.26 ± 6.931.84 ± 0.381.22 ± 0.358.88 ± 0.32161.80 ± 5.360.45 ± 0.0150.74 ± 0.9418.22 ± 0.33359.60 ± 3.51817.20 ± 97.763.79 ± 0.6023.94 ± 4.60
72021.38 ± 5.6475.60 ± 5.431.60 ± 0.741.42 ± 0.488.99 ± 0.30160.60 ± 7.230.44 ± 0.0249.30 ± 2.4917.88 ± 0.81362.80 ± 2.39900.00 ± 129.283.73 ± 0.6221.50 ± 5.65

Data represent the mean values and the standard deviation.
: only parameters with statistically significant findings are shown in table.
and ∗∗P < 0.01, statistical significances were determined with Duncan's multiple range test or with Mann–Whitney test versus control.
: minimum and maximum levels reported as the range of historical control values.