Table 9
(a) Summary of food consumption in the 90-day repeated oral toxicity study

Group (mg/kg bw/day)Daily mean food consumption (g/animal/d) on weeks
12345678910111213

Males
 Control20.2 ± 1.6021.1 ± 1.6823.1 ± 1.8122.0 ± 1.5020.3 ± 1.5120.4 ± 2.0418.8 ± 1.6219.6 ± 1.5519.4 ± 1.2817.8 ± 1.6019.8 ± 1.7218.0 ± 1.8316.1 ± 1.52
 10020.5 ± 1.6820.3 ± 2.9822.8 ± 3.3422.1 ± 3.3720.6 ± 2.7419.8 ± 2.4918.7 ± 2.5917.4 ± 2.09∗∗18.1 ± 1.9616.8 ± 2.0218.0 ± 1.9416.9 ± 1.9415.3 ± 1.63
 36016.7 ± 1.64∗∗17.9 ± 1.18∗∗20.1 ± 1.03∗∗19.7 ± 1.35∗∗18.4 ± 1.6117.9 ± 2.2316.9 ± 2.2315.5 ± 1.78∗∗16.9 ± 1.66∗∗16.4 ± 1.6816.7 ± 1.87∗∗16.2 ± 2.3214.0 ± 1.45∗∗
 72014.6 ± 1.17∗∗16.9 ± 1.19∗∗18.9 ± 1.21∗∗18.6 ± 0.81∗∗17.8 ± 0.93∗∗17.5 ± 0.82∗∗16.3 ± 1.29∗∗15.8 ± 1.09∗∗16.6 ± 0.91∗∗16.3 ± 1.1616.6 ± 1.14∗∗15.9 ± 1.39∗∗13.8 ± 1.36∗∗

Females
 Control14.3 ± 1.0013.5 ± 1.0716.2 ± 1.3915.8 ± 1.9315.0 ± 2.6415.7 ± 2.1115.0 ± 2.0415.6 ± 2.1716.7 ± 2.2214.6 ± 1.8216.0 ± 1.9515.0 ± 1.9813.6 ± 1.65
 10014.2 ± 1.5813.3 ± 1.3314.9 ± 1.3615.1 ± 1.3814.3 ± 1.6614.0 ± 1.24∗∗13.5 ± 1.7712.9 ± 1.32∗∗14.2 ± 1.43∗∗13.5 ± 1.8114.3 ± 1.8613.6 ± 2.0712.3 ± 2.07
 36011.7 ± 0.81∗∗11.8 ± 0.92∗∗14.1 ± 0.88∗∗14.2 ± 0.8313.6 ± 0.9713.1 ± 1.27∗∗12.3 ± 1.23∗∗11.9 ± 1.37∗∗13.5 ± 1.03∗∗11.7 ± 1.56∗∗12.6 ± 1.63∗∗11.9 ± 1.83∗∗10.5 ± 1.84∗∗
 72010.4 ± 1.28∗∗11.5 ± 1.23∗∗14.0 ± 0.95∗∗14.1 ± 1.15∗∗13.1 ± 1.2412.7 ± 1.11∗∗12.0 ± 1.27∗∗11.3 ± 1.22∗∗12.5 ± 0.92∗∗11.3 ± 1.16∗∗12.0 ± 1.22∗∗11.7 ± 1.26∗∗10.1 ± 1.31∗∗

= 15 for control and 720 mg/kg bw/day groups and = 10 for all other groups.
p < 0.05, ∗∗p < 0.01, statistical significances were determined with Duncan’s multiple range test or with Mann–Whitney test versus control.
(b) Summary of food consumption in the recovery period

Group (mg/kg bw/day)Mean food consumption (g/animal/d) on weeks
1234

Males
 Control23.9 ± 1.225.5 ± 1.224.5 ± 1.123.9 ± 1.0
 72019.7 ± 1.7∗∗24.2 ± 1.422.6 ± 1.822.7 ± 2.0

Females
 Control15.9 ± 1.117.9 ± 1.716.2 ± 1.116.5 ± 1.1
 72012.8 ± 1.3∗∗15.4 ± 1.813.5 ± 2.514.9 ± 0.9

= 5 for all groups.
p < 0.05, ∗∗p < 0.01, statistical significances were determined with Duncan’s multiple range test or with Mann–Whitney test versus control.