Toxicity Evaluation of a Novel Magnetic Resonance Imaging Marker, CoCl2-N-Acetylcysteine, in Rats
Table 1
Hematologic findings.
Time after Injection and Treatment Group
MCV, fL
MCHC, g/dL
Neutrophils
Monocytes
Lymphocytes
×103/L
×103/L
×103/L
Day 2
Control
61.7 (57.8-64.0)
30.8 (29.1-32.6)
2.3 (1.04-2.99)
18.4 (10.4-24.9)
0.27 (0.10-0.43)
2.1 (1.0-2.7)
9.63 (6.76-11.84)
76.6 (68.7-87.2)
Low dose
61.1 (57.1-63.3)
30.9 (29.5-32.1)
3.1 (1.67-4.63)
21.6 (15.3-27.9)
0.33 (0.25-0.56)
2.3 (1.8-2.8)
10.5 (8.43-15.38)
72.5 (66.7-80.9)
Ref dose
61.3 (57.8-62.9)
30.1 (29.4-30.6)
3.1 (0.9-5.27)
20.1 (11.2-26.7)
0.33 (0.09-0.54)
2.1 (1.2-2.8)
10.1 (6.84-15.13)
74.7 (67.0-85.4)
High dose
58.5 (56.8-60.0)
30.9 (30.2-31.7)
3.5 (2.15-4.64)
26.6 (19.0-34.4)
0.4 (0.27-0.87)
2.9 (2.0-5.4)
8.7 (6.75-10.15)
66.7 (58-75.3)
Day 28
Control
58.7 (58-59.6)
30.5 (30.3-30.7)
2.21 (1.03-2.87)
22.1 (11.6-28.4)
0.22 (0.16-0.3)
2.2 (1.5-2.9)
6.99 (6.31-7.39)
71.7 (62.4-82.9)
Low dose
59.3 (56.5-62.0)
30.5 (30.1-30.9)
2.5 (1.31-3.95)
21.6 (15-34.4)
0.27 (0.18-0.35)
2.5 (1.5-4.0)
8.3 (6.23-13.28)
71.6 (55.6-80)
Ref dose
58.8 (57.3-59.8)
31.1 (29.8-31.7)
2.3 (1.08-3.57)
24.2 (13.1-37.1)
0.31 (0.16-0.56)
31. (1.9-5.9)
6.8 (5.26-9.78)
69.4 (54.8-81.5)
High dose
58.8 (56.5-60.1)
30.6 (29.8-31.4)
2.7 (2.07-3.20)
23.1 (20.1-26.8)
0.31 (0.20-0.53)
2.7 (1.9-4.8)
8.2 (7.05-10.87)
70.4 (63.5-73.8)
Day 63
Control
58.8 (57.7-61.2)
30.9 (30.6-31.4)
1.65 (0.95-2.29)
15 (8.9-20.3)
0.22 (0.16-0.37)
2 (1.3-3.3)
8.83 (7.43-9.96)
80.5 (73.2-87.0)
Low dose
58.9 (57.0-60.5)
31.9 (31.0-32.5)
2.0 (1.16-2.52)
16.2 (12.0-19.4)
0.26 (0.19-0.35)
2.2 (1.5-3.1)
9.3 (8.03-10.75)
78.5 (74.7-83.6
Ref dose
58.7 (57.2-60.7)
32.2 (32-32.5)
1.8 (1.06-2.68)
15.7 (10.1-24.2)
0.23 (0.11-0.34)
2.0 (1.3-3.2)
8.8 (7.01-11.99)
78.6 (69.6-85.3)
High dose
57.8 (55.8-61.1)
31.4 (30.1-32.3)
1.6 (1.0-2.38)
12.6 (6.9-16.8)
0.25 (0.09-0.38)
1.9 (0.9-2.7)
10.4 (9.13-12.91)
82.8 (78.0-89.9)
Data are shown as mean (range).Significantly different from control at P< 0.05. Control, 0% CoCl2:NAC; Low dose, 0.1% CoCl2:2% NAC; Ref[erence] dose 1% CoCl2:2% NAC; High dose, 10% CoCl2:2% NAC. MCV, mean corpuscular volume (in femtoliters); MCHC, mean corpuscular hemoglobin concentration.
