Journal of Toxicology / 2019 / Article / Tab 3

Research Article

Potential Toxicity of the Essential Oil from Minthostachys mollis: A Medicinal Plant Commonly Used in the Traditional Andean Medicine in Peru

Table 3

Haematological parameters of rats after treatment with repeated oral doses of Minthostachys mollis essential oil (Mm-EO) for 28 days.

ParametersControlMm-EO 100Mm-EO 250Mm-EO 500

Males
RBC (×106/µL)7.22 ± 0.177.42 ± 0.227.17 ± 0.29n.d.
WBC (×103/µL)8.10 ± 0.668.43 ± 0.858.50 ± 0.82n.d.
Hemoglobin (g/dL)14.73 ± 0.8514.47 ± 0.4714.33 ± 0.67n.d.
Hematocrit (%)46.67 ± 2.0846.33 ± 3.5545.97 ± 1.29n.d.
Neutrophils (%)18.67 ± 1.5323.33 ± 3.5124.67 ± 4.51n.d.
Eosinophils (%)2.67 ± 0.582.33 ± 0.582.67 ± 1.15n.d.
Basophils (%)1.33 ± 1.531.00 ± 1.001.00 ± 1.00n.d.
Monocytes (%)3.33 ± 0.583.00 ± 1.153.00 ± 1.00n.d.
Lymphocytes (%)74.00 ± 3.6067.33 ± 6.5668.67 ± 5.86n.d.
Platelets (×103/µL)707.33 ± 42.45716.67 ± 35.11748.33 ± 50.58n.d.

Females
RBC (×106/µL)7.17 ± 0.296.95 ± 0.256.91 ± 0.197.05 ± 0.17
WBC (×103/µL)8.03 ± 0.458.73 ± 0.6710.13 ± 2.9510.26 ± 2.15
Hemoglobin (g/dL)13.83 ± 1.8913.67 ± 1.0413.60 ± 1.6513.47 ± 0.65
Hematocrit (%)42.63 ± 5.7342.53 ± 3.7242.33 ± 3.4942.23 ± 2.11
Neutrophils (%)19.00 ± 1.5323.67 ± 4.1624.67 ± 4.1627.33 ± 2.52
Eosinophils (%)2.33 ± 0.581.67 ± 1.522.00 ± 1.002.00 ± 1.00
Basophils (%)1.00 ± 1.000.67 ± 1.151.00 ± 1.000.67 ± 0.58
Monocytes (%)2.67 ± 1.152.00 ± 1.002.67 ± 2.082.33 ± 0.58
Lymphocytes (%)75.00 ± 2.6472.00 ± 6.2469.67 ± 6.5167.67 ± 4.04
Platelets (×103/µL)696.33 ± 26.95747.00 ± 43.97690.00 ± 29.31738.33 ± 15.01

Values are expressed as Mean ± SD, significance when compared with control (). One-way ANOVA followed by Tukey test. RBC, Red blood cell; WBC, White blood cell. n.d., not determined because rats died in the first week of treatment.