Antioxidant Potential, Subacute Toxicity, and Beneficiary Effects of Methanolic Extract of Pomelo (Citrus grandis L. Osbeck) in Long Evan Rats
Table 4
The effects of different concentrations methanolic extract of pomelo on the hematological parameters of whole blood.
Hematological parameters
Control
250 mg/kg
500 mg/kg
1000 mg/kg
RBC (10∧6/μL)
7.41 ± 0.97
7.24 ± 0.48
6.56 ± 0.43
7.26 ± 1.32
HGB (g/dL)
14.10 ± 1.83
13.86 ± 0.90
12.64 ± 0.73
13.81 ± 2.52
HCT (%)
38.98 ± 4.82
38.26 ± 2.26
35.10 ± 1.82
38.90 ± 6.53
MCV (fL)
52.78 ± 1.19
52.88 ± 0.88
53.54 ± 1.03
53.75 ± 3.32
MCH (pg)
19.08 ± 0.42
19.16 ± 0.47
19.28 ± 0.37
19.02 ± 0.60
MCHC (g/dL)
36.13 ± 0.70
36.22 ± 0.45
36.00 ± 0.35
35.45 ± 1.24
RDW-SD (fL)
32.41 ± 2.81
33.14 ± 1.82
31.10 ± 1.25
34.50 ± 3.92
RDW-CV (%)
20.98 ± 2.48
21.02 ± 1.02
19.06 ± 1.23
21.40 ± 1.55
WBC (10∧3/μL)
4.55 ± 1.32
4.48 ± 0.90
4.94 ± 1.14
4.27 ± 1.70
LYMPH (%)
2.79 ± 1.08
2.83 ± 0.66
3.34 ± 0.83
2.68 ± 1.20
MONO (%)
0.05 ± 0.01
0.05 ± 0.01
0.05 ± 0.02
0.04 ± 0.01
GRANULOCYTES (%)
0.01 ± 0.01
0.15 ± 0.06
0.04 ± 0.06
0.03 ± 0.03
PLT (10∧3/μL)
4.55 ± 1.32
4.48 ± 0.90
4.94 ± 1.14
4.27 ± 1.70
MPV (fL)
9.48 ± 0.31
9.48 ± 0.34
9.40 ± 0.18
9.16 ± 0.26
PDW (fL)
10.85 ± 0.71
10.94 ± 0.62
10.40 ± 0.31
10.30 ± 0.54
PCT (%)
0.77 ± 0.11
0.79 ± 0.04
0.78 ± 0.04
0.76 ± 0.11
P-LCR (%)
21.21 ± 2.68
21.44 ± 3.11
20.18 ± 1.55
19.01 ± 2.19
Results are expressed as mean ± SD (n=8). HGB: hemoglobin, HCT: hematocrit, MCV: mean corpuscular volume, MCH: mean corpuscular hemoglobin, MCHC: mean corpuscular hemoglobin concentration, PLT: platelets, RDW-SD: red cell distribution width-standard deviation, RDW-CV: red cell distribution width-coefficient of variation, PDW-CV: platelets distribution width, MPV: mean platelets volume, P-LCR: platelets larger cell ratio, and PCT: procalcitonin. No significant changes were found when all treatment groups were compared against the control based on a one-way ANOVA followed by Dunnett’s multiple comparison tests.
