Safety Assessment of Ubiquinol Acetate: Subchronic Toxicity and Genotoxicity Studies
Table 10
Effect of ubiquinol acetate on clinical chemistry parameters in female rats.
Parameters
Units
Group & Dose (mg/kg b.w.)
G1,
G2,
G3,
G4,
G1R,
G4R,
0
150
300
600
0
600
Glucose
mg/dL
124.50±25.44
105.90±17.91
116.3±12.03
111.40±12.61
122.2±8.11
116.20±9.78
Blood Urea Nitrogen
mg/dL
18.20±2.30
19.50±2.22
20.50±3.44
21.30±3.83
11.20±3.96
13.20±2.77
Creatinine
mg/dL
0.46±0.10
0.44±0.07
0.49±0.10
0.49±0.05
0.27±0.02
0.34±0.05
Cholesterol
mg/dL
86.70±18.78
91.60±17.99
87.40±22.80
90.20±19.87
103.40±9.86
120.20±23.83
TGL
mg/dL
31.90±11.94
34.90±5.59
31.20±7.94
34.10±8.18
31.80±9.20
25.60±4.93
Total Protein
g/dL
6.92±0.39
7.02±0.37
6.78±0.27
7.16±0.46
6.66±0.26
6.66±0.48
Albumin
g/dL
1.53±0.16
1.56±0.13
1.41±0.13
1.47±0.30
1.40±0.19
1.12±0.19
Total Bilirubin
mg/dL
0.11±0.06
0.08±0.09
0.07±0.05
0.11±0.06
0.10±0.07
0.06±0.05
AST
U/L
71.10±15.07
87.80±34.78
89.80±19.10
118.20±42.65
70.60±16.04
82.00±12.88
Calcium
mg/dL
9.80±0.39
9.90±0.22
9.39±0.28
9.28±1.66
9.02±0.31
9.20±0.33
Phosphorus
mg/dL
5.24±0.67
4.99±0.47
5.44±0.53
5.28±0.48
5.10±0.31
5.22±0.28
ALP
U/L
64.30±11.45
66.40±16.13
77.20±15.40
83.30±33.68
40.00±10.56
45.60±4.88
ALT
U/L
13.10±2.60
20.30±6.48
23.10±6.61
31.30±14.67
16.60±3.05
21.80±2.95
GGT
U/L
2.40±1.26
2.30±1.34
3.00±0.82
2.20±1.48
5.40±1.34
5.20±1.30
Sodium
mmol/L
135.14±1.78
135.84±1.55
135.18±1.56
136.30±2.02
137.52±0.76
136.92±0.36
Potassium
mmol/L
4.00±0.34
3.76±0.24
3.87±0.30
3.87±0.27
4.16±0.25
4.11±0.33
Chloride
mmol/L
107.81±1.41
107.77±1.38
107.23±1.27
108.72±1.62
107.60±0.74
107.58±0.86
Globulin
g/dL
5.35±0.32
5.46±0.33
5.35±0.22
5.69±0.35
5.26±0.18
5.54±0.47
Mean ± SD for 10 rats/sex/group (G1, G2, G3, G4) and 5 rats/sex/group (G1R, G4R); : statistically significant compared to the control group (p < 0.05).
