Safety Assessment of Ubiquinol Acetate: Subchronic Toxicity and Genotoxicity Studies
Table 11
Effect of ubiquinol acetate on absolute organ weights.
Organ
Sex
Group & Dose (mg/kg b.w.)
G1,
G2,
G3,
G4,
G1R,
G4R,
0
150
300
600
0
600
Kidneys
Male
3.5127±0.3930
3.3681±0.4378
3.4254±0.6575
3.6245±0.3467
2.9478±0.3413
3.4107±0.382
Female
2.0625±0.3258
1.8507±0.1611
1.9465±0.1566
1.9238±0.1899
1.9870±0.2523
2.1070±0.2536
Adrenals
Male
0.0641±0.0142
0.0721±0.0184
0.0650±0.0170
0.0665±0.0148
0.0451±0.0096
0.0575±0.0074
Female
0.0716±0.0089
0.0743±0.0135
0.0749±0.0090
0.1521±0.2338
0.0712±0.0140
0.0732±0.0095
Spleen
Male
0.9394±0.1453
0.8933±0.1381
0.9379±0.1544
1.0691±0.2414
0.7964±0.1151
0.9713±0.1424
Female
0.6409±0.0939
0.5568±0.0705
0.6637±0.0759
0.7218±0.1514
0.6675±0.1877
0.7605±0.1765
Heart
Male
1.6051±0.1723
1.6878±0.2243
1.6721±0.1998
1.6202±0.1868
1.5127±0.1457
1.5358±0.0668
Female
1.0702±0.1039
0.9925±0.0573
0.9922±0.0791
1.0658±0.0987
1.0543±0.1028
1.0918±0.0728
Liver
Male
17.5704±2.2358
16.2747±2.6032
16.6456±3.3436
18.0420±2.9797
14.4688±1.7072
15.9630±1.6045
Female
9.1951±1.1801
8.3073±1.0307
8.3006±0.6693
9.2363±1.1137
8.9485±1.1943
9.3907±0.7840
Thymus
Male
0.4835±0.1050
0.5787±0.0902
0.5553±0.1422
0.6622±0.133
0.4977±0.0706
0.4989±0.1741
Female
0.4626±0.1532
0.3649±0.0731
0.4044±0.0869
0.3860±0.0728
0.4369±0.1188
0.4679±0.1589
Brain
Male
2.3552±0.1246
2.3494±0.1032
2.2999±0.1290
2.2327±0.1292
2.2089±0.1059
2.3116±0.0853
Female
2.1233±0.1200
2.0894±0.1806
2.1484±0.0966
2.0909±0.1055
2.1446±0.1097
2.1692±0.0615
Testes
Male
4.0722±0.3766
4.1204±0.3059
3.9762±0.5078
4.0524±0.2852
3.7692±0.3181
3.9867±0.0434
Epididymides
Male
1.6995±0.2227
1.6857±0.1587
1.4988±0.2433
1.6142±0.1712
1.4772±0.961
1.5197±0.1067
PSVC
Male
3.6996±0.7613
3.3859±0.6118
3.3255±0.5844
3.1484±0.4997
2.6255±0.2869
3.4107±0.382
Ovaries
Female
0.1454±0.0341
0.1217±0.0274
0.1289±0.0185
0.1337±0.0363
0.1291±0.0190
0.1348±0.0083
Uterus
Female
0.9388±0.3061
1.1497±0.5136
1.1038±0.5532
1.2858±0.7225
1.5083±0.9090
1.3469±0.6788
Mean ± SD for 10 rats/sex/group (G1, G2, G3, G4) and 5 rats/sex/group (G1R, G4R); : statistically significant compared to the control group (p < 0.05).
