Safety Assessment of Ubiquinol Acetate: Subchronic Toxicity and Genotoxicity Studies

Table 12

Effect of ubiquinol acetate on relative organ weights (%).

Organ	Sex	Group & Dose (mg/kg b.w.)
		G1,	G2,	G3,	G4,	G1R,	G4R,
		0	150	300	600	0	600
Kidneys	Male	0.7232±0.0792	0.7257±0.0882	0.7168±0.0889	0.7704±0.0929	0.6495±0.0499	0.7258±0.051
	Female	0.7810±0.0837	0.7552±0.0768	0.7651±0.0862	0.7580±0.1307	0.7703±0.0721	0.7748±0.0747
Adrenals	Male	0.0131±0.0025	0.0155±0.0038	0.0138±0.0040	0.0140±0024	0.0100±0.0025	0.0124±0.0021
	Female	0.0276±0.0055	0.0303±0.0055	0.0294±0.0035	0.0618±0.0991	0.0266±0.0064	0.0271±0.0046
Spleen	Male	0.1931±0.0272	0.1931±0.0330	0.1975±0.0286	0.2250±0.0415	0.1757±0.0223	0.2093±0.0322
	Female	0.2434±0.0290	0.2269±0.0292	0.2603±0.0313	0.2798±0.0451	0.2194±0.0388	0.2791±0.0561
Heart	Male	0.3303±0.0308	0.3632±0.0429	0.3527±0.0385	0.3425±0.0270	0.3335±0.0201	0.3310±0.0237
	Female	0.4084±0.0452	0.4052±0.0318	0.3897±0.0395	0.4174±0.0539	0.3950±0.0448	0.4019±0.0164
Liver	Male	3.6062±0.3184	3.5019±0.5405	3.4752±0.4577	3.8245±0.6361	3.1830±0.1809	3.4402±0.3901
	Female	3.4989±0.3900	3.3898±0.4581	3.2648±0.3799	3.6217±0.5849	3.2776±03004	3.4542±0.1666
Thymus	Male	0.1000±0.0242	0.1244±0.0169	0.1186±0.0382	0.1403±0.028	0.1098±0.0133	0.1075±0.0373
	Female	0.1736±0.0472	0.1478±0.0239	0.1574±0.0269	0.1508±0.0271	0.1587±0.0323	0.1730±0.0623
Brain	Male	0.4855±0.0356	0.5089±0.0549	0.4877±0.0564	0.4745±0.0420	0.4889±0.0389	0.4982±0.0333
	Female	0.8135±0.0990	0.8527±0.0879	0.8434±0.0579	0.8216±0.1089	0.8317±0.1305	0.8003±0.0493
Testes	Male	0.8381±0.0739	0.8934±0.1197	0.8371±0.0862	0.8593±0.0587	0.8314±0.0444	0.8588±0.0350
Epididymides	Male	0.3511±0.0544	0.3645±0.0447	0.3150±0.0395	0.3430±0.0436	0.3256±0.0340	0.3278±0.0328
PSVC	Male	0.7677±0.1872	0.7281±0.1176	0.6993±0.1007	0.6726±0.1355	0.5811±0.0714	0.7338±0.076
Ovaries	Female	0.0554±0.0124	0.0497±0.0114	0.0504±0.0065	0.0519±0.0129	0.0483±0.0123	0.0498±0.0052
Uterus	Female	0.3569±0.1083	0.4671±0.2051	0.4354±0.2283	0.5023±0.2869	0.6827±0.5235	0.4912±0.2288

Mean ± SD for 10 rats/sex/group (G1, G2, G3, G4) and 5 rats/sex/group (G1R, G4R);: statistically significant compared to the control group (p < 0.05).