Safety Assessment of Ubiquinol Acetate: Subchronic Toxicity and Genotoxicity Studies

Table 6

Effect of ubiquinol acetate on mean body weight gain (%).

Duration; (Weeks)	Sex	Group & Dose (mg/kg body weight)
		G1	G2	G3	G4	G1R	G4R
		0	150	300	600	0	600
1	Male	33.57 ± 2.78	32.07 ± 3.25	32.38 ± 3.03	33.89 ± 4.74	33.79 ± 2.81	34.56 ± 1.73
	Female	21.66 ± 5.11	18.55 ± 5.12	18.41 ± 4.42	20.34 ± 7.92	17.92 ± 4.32	21.23 ± 4.89
5	Male	117.76 ± 8.92	111.86 ± 20.18	114.20 ± 9.91	117.73 ± 19.00	117.59 ± 18.68	119.14 ± 5.95
	Female	53.21 ± 7.98	49.24 ± 6.68	52.34 ± 6.31	56.37 ± 8.10	55.15 ± 12.11	57.96 ± 9.53
9	Male	155.19 ± 13.63	144.19 ± 28.58	148.05 ± 12.17	155.12 ± 26.99	151.72 ± 25.47	150.03 ± 17.40
	Female	79.38 ± 12.25	73.12 ± 9.25	82.19 ± 11.95	77.60 ± 9.00	84.14 ± 14.98	83.03 ± 11.99
13	Male	174.36 ± 16.57	166.61 ± 33.70	168.17 ± 12.89	174.14 ± 31.09	168.81 ± 24.19	172.71 ± 21.19
	Female	85.17 ± 15.08	78.90 ± 12.56	86.19 ± 13.51	84.46 ± 11.19	88.71 ± 20.10	97.93 ± 15.37
15	Male	-	-	-	-	175.10 ± 23.79	179.42 ± 20.88
	Female	-	-	-	-	87.00 ± 20.58	97.85± 10.41

Mean ± SD for 10 rats/sex/group (G1, G2, G3, G4) and 5 rats/sex/group (G1R, G4R).