Safety Assessment of Ubiquinol Acetate: Subchronic Toxicity and Genotoxicity Studies

Table 7

Effect of ubiquinol acetate on hematological parameters in male rats.

Parameters	Units	Group & Dose (mg/kg b.w.)
		G1,	G2,	G3,	G4,	G1R,	G4R,
		0	150	300	600	0	600
Total WBC count	10^3/μl	6.50 ± 0.99	6.79 ± 0.86	6.76± 1.03	6.63 ± 1.38	6.00±1.18	7.25±1.72
Total RBC count	10^6/μl	9.04 ± 0.51	9.11 ± 0.34	8.83± 0.41	8.64± 0.33	8.60±0.70	8.61±0.6
Hemoglobin	g/dL	15.62±0.48	15.58±0.38	15.64±0.46	14.85±0.61	15.90±0.93	15.42±0.76
Hematocrit	%	48.22±1.97	48.48±1.74	48.46±1.78	45.67±2.11	46.34±3.56	45.2±2.93
MCV	fL	53.39±1.92	53.28±2.94	54.94±1.52	52.92±3.01	53.90±1.91	52.54±1.83
MCH	pg	17.28±0.72	17.12±0.84	17.72±0.61	17.22±1.00	18.54±0.7	17.94±0.63
MCHC	g/dL	32.39±0.67	32.15±0.59	32.28±0.62	32.54±0.64	34.40±0.58	34.16±0.64
Neutrophils	10^3/μl	1.02±0.26	1.35±0.49	1.41±0.51	1.32±0.72	0.98±0.36	1.07±0.27
Lymphocytes	10^3/μl	5.07±0.88	5.01±0.75	4.95±0.56	4.91±1.04	4.64±0.92	5.78±1.40
Monocytes	10^3/μl	0.21±0.08	0.18±0.05	0.18±0.06	0.17±0.07	0.18±0.06	0.22±0.12
Eosinophils	10^3/μl	0.11±0.04	0.13±0.04	0.11±0.05	0.11±0.04	0.15±0.04	0.13±0.05
Basophils	10^3/μl	0.01±0.00	0.01±0.01	0.01±0.00	0.01±0.00	0.01±0.01	0.01±0.00
LUC	10^3/μl	0.09±0.03	0.11±0.04	0.09±0.05	0.11±0.05	0.03±0.03	0.05±0.03
Platelet count	10^3/μl	777.0±83.43	637.30±146.39	688.90±185.00	845.80±105.67	732.20±154.39	931.40±123.82
Blood clotting time	Seconds	154.20±11.64	165.10±23.39	165.80±23.72	154.90±27.74	169.00±28.52	164.60±27.41

Mean ± SD for 10 rats/sex/group (G1, G2, G3, G4) and 5 rats/sex/group (G1R, G4R); : statistically significant compared to the control group (p < 0.05).