Safety Assessment of Ubiquinol Acetate: Subchronic Toxicity and Genotoxicity Studies

Table 8

Effect of ubiquinol acetate on hematological parameters in female rats.

Parameters	Units	Group & Dose (mg/kg b.w.)
		G1,	G2,	G3,	G4,	G1R,	G4R,
		0	150	300	600	0	600
Total WBC count	10^3/μl	5.04±1.49	4.25 ± 0.99	5.13± 1.16	5.49±2.89	5.03±1.53	5.33±1.58
Total RBC count	10^6/μl	8.06±0.33	8.31 ± 0.30	8.09± 0.27	8.08± 0.35	8.18±0.32	7.94±0.24
Hemoglobin	g/dL	14.88±0.58	15.17±0.46	14.65±0.39	14.76±0.54	15.84±0.29	15.54±0.39
Hematocrit	%	45.24±1.86	45.10±1.04	43.55±0.92	43.54±1.80	45.42±1.86	43.48±1.00
MCV	fL	56.12±1.02	54.32±1.29	53.88±1.85	53.94±0.69	55.50±0.91	54.8±1.80
MCH	pg	18.47±0.31	18.27±0.42	18.14±0.71	18.31±0.46	19.36±0.47	19.6±0.24
MCHC	g/dL	32.90±0.31	33.66±0.44	33.62±0.52	33.95±0.65	34.90±0.86	35.76±0.85
Neutrophils	10^3/μl	0.99±0.51	0.72±0.17	1.03±0.49	1.35±1.27	0.62±0.26	0.95±0.42
Lymphocytes	10^3/μl	3.75±1.04	3.28±0.83	3.81±0.82	3.81±1.90	4.13±1.54	4.05±1.20
Monocytes	10^3/μl	0.12±0.03	0.11±0.04	0.12±0.03	0.14±0.06	0.11±0.05	0.16±0.04
Eosinophils	10^3/μl	0.11±0.06	0.07±0.02	0.10±0.07	0.11±0.08	0.13±0.09	0.12±0.06
Basophils	10^3/μl	0.01±0.01	0.00±0.00	0.01±0.01	0.01±0.01	0.01±0.01	0.01±0.00
LUC	10^3/μl	0.06±0.02	0.07±0.03	0.07±0.02	0.08±0.04	0.03±0.01	0.04±0.01
Platelet count	10^3/μl	783.10±190.59	790.40±263.71	691.10±185.00	834.80±295.27	934.6±240.07	858.4±291.48
Blood clotting time	Seconds	155.80±14.80	154.70±14.58	158.30±16.23	144.50±24.34	152.40±16.02	214±33.94

Mean ± SD for 10 rats/sex/group (G1, G2, G3, G4) and 5 rats/sex/group (G1R, G4R);: statistically significant compared to the control group (p < 0.05).