A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin

Table 9

Summary of histopathology findings in the 90-day study.

Organs	Observations	Incidence of observations per group
		Control	500	1000	2000
			mg/kg bw/day	mg/kg bw/day	mg/kg bw/day
Males
Epididymides	Sperm granuloma (one side)	0/10	1/1	/	0/10
Kidneys	Pyelectasia	0/10	2/2	2/2	1/10
Liver capsule	Focal fibrosis in the Glisson’s	0/10	/	/	1/10
Lungs	Alveolar emphysema	1/10	/	/	0/10
	Hyperplasia of BALT	1/10	/	/	1/10
Females
Kidneys	Pyelectasia	1/10	/	1/1	2/10
Liver	Focal fibrosis in Glisson’s capsule	0/10	/	/	1/10
Lungs	Alveolar emphysema	1/10	/	/	0/10
	Hyperplasia of BALT	1/10	/	/	1/10
	Bronchitis	0/10	/	/	1/10
Skin	Atrophy of hair follicles (focal)	0/10	/	1/1	0/10
Spleen	Hyperplasia (focal)	0/10	/	/	1/10
Uterus	Dilatation	3/10	/	/	3/10

incidence: number of animals with observations/number of animals examined
/: not examined; BALT: bronchus associated lymphoid tissue.