Journal of Toxicology / 2019 / Article / Tab 10

Research Article

A Toxicological Evaluation of Methylliberine (Dynamine®)

Table 10

Percent organ weights and body weight relative to brain weight in the 90-day study.

Group (mg/kg bw/day)Body weightLiverKidneysHeartSpleenThymusTestesEpididymidesAdrenal glands

Main study groups
Male
0 (Control)Mean18884.1450.56104.7748.8830.6218.64164.9768.883.14
SD1185.1534.645.102.365.062.847.923.630.28
75Mean19369.0508.54117.9649.0033.2616.67173.9268.013.38
SD1497.3040.1814.454.073.921.7912.279.210.50
SS
112Mean19038.2514.06119.3147.8331.6213.78164.4964.173.12
SD740.1929.3811.023.883.402.3112.189.980.49
SS
150Mean18316.5505.15120.7246.3828.6112.70158.0059.713.29
SD1184.7549.6810.543.014.431.9420.197.310.65
SS
187Mean17807.0513.9123.745.629.512.8159.358.43.3
SD1140.8040.8614.544.613.662.719.796.410.56
SS
225Mean15657.1476.4118.742.126.510.998.852.33.3
SD1229.1649.528.883.804.431.9047.5412.610.60
SS
Test for significanceDNDNDNDNDNDNNS
Historical control range16500.0–24796.4375.45–660.6388.64–114.3442.73–61.9922.47–41.1511.31–26.29146.64–196.0255.16–85.651.95–4.27

FemaleOvariesUterus
0 (Control)Mean12265.9309.1878.8036.4423.1617.1431.914.744.20
SD607.5126.155.432.162.602.686.160.940.59
75Mean12201.0372.6385.5436.8826.0114.7935.595.113.99
SD575.8338.754.723.552.103.326.070.990.39
SS
112Mean12500.9410.7192.2938.1827.0315.6633.915.173.98
SD979.4781.728.774.434.974.227.881.160.65
SS
150Mean12877.3434.4890.8239.2425.4712.9830.446.203.91
SD987.8751.276.192.983.651.954.901.090.50
SS
187Mean12704.5457.8493.3138.9025.3115.5232.066.393.78
SD663.3150.355.063.022.474.106.481.570.51
SS
225Mean12648.4481.2593.0238.7324.0412.2328.716.903.66
SD894.7660.749.132.632.321.995.831.420.56
SS
Test for significanceNSDNNSNSDNNSDNNS
Historical control range10000.0–13686.6263.82–408.7466.67–125.8130.29–44.0917.11–28.878.96–21.8620.85–51.633.49–7.002.99–5.56
Recovery groups
MaleTestesEpididymides
0 (Control)Mean20125.0467.52111.6350.5030.2015.00154.8371.652.79
SD1271.1735.9711.763.411.853.219.874.900.30
225Mean18964.2460.18119.6352.1638.2021.44114.5659.612.84
SD1517.8043.828.625.602.961.5746.715.880.45
SS
Test for significanceNSNSNSNSNSNS

FemaleOvariesUterus
0 (Control)Mean11754.7288.3874.7735.7022.7112.1930.084.403.40
SD851.7723.8412.024.251.703.266.830.530.22
225Mean12010.5342.7082.0238.4324.9518.1638.574.943.83
SD731.3841.116.491.423.323.035.940.680.55
SS
Test for significanceNSNSNSNSNSNSNS

Abbreviations: DN, Duncan’s multiple range test; NS, not significant; SD, standard deviation; SS, statistically significant compared to control; -test versus control; , Mann-Whitney -test versus control.Remarks: Paired organs were weighed together..

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