A Toxicological Evaluation of Methylliberine (Dynamine®)

Table 10

Percent organ weights and body weight relative to brain weight in the 90-day study.

Group (mg/kg bw/day)		Body weight	Liver	Kidneys	Heart	Spleen	Thymus	Testes	Epididymides	Adrenal glands
Main study groups
Male
0 (Control)	Mean	18884.1	450.56	104.77	48.88	30.62	18.64	164.97	68.88	3.14
	SD	1185.15	34.64	5.10	2.36	5.06	2.84	7.92	3.63	0.28
75	Mean	19369.0	508.54	117.96	49.00	33.26	16.67	173.92	68.01	3.38
	SD	1497.30	40.18	14.45	4.07	3.92	1.79	12.27	9.21	0.50
	SS
112	Mean	19038.2	514.06	119.31	47.83	31.62	13.78	164.49	64.17	3.12
	SD	740.19	29.38	11.02	3.88	3.40	2.31	12.18	9.98	0.49
	SS
150	Mean	18316.5	505.15	120.72	46.38	28.61	12.70	158.00	59.71	3.29
	SD	1184.75	49.68	10.54	3.01	4.43	1.94	20.19	7.31	0.65
	SS
187	Mean	17807.0	513.9	123.7	45.6	29.5	12.8	159.3	58.4	3.3
	SD	1140.80	40.86	14.54	4.61	3.66	2.71	9.79	6.41	0.56
	SS
225	Mean	15657.1	476.4	118.7	42.1	26.5	10.9	98.8	52.3	3.3
	SD	1229.16	49.52	8.88	3.80	4.43	1.90	47.54	12.61	0.60
	SS
Test for significance		DN	DN	DN	DN	DN	DN			NS
Historical control range		16500.0–24796.4	375.45–660.63	88.64–114.34	42.73–61.99	22.47–41.15	11.31–26.29	146.64–196.02	55.16–85.65	1.95–4.27
Female								Ovaries	Uterus
0 (Control)	Mean	12265.9	309.18	78.80	36.44	23.16	17.14	31.91	4.74	4.20
	SD	607.51	26.15	5.43	2.16	2.60	2.68	6.16	0.94	0.59
75	Mean	12201.0	372.63	85.54	36.88	26.01	14.79	35.59	5.11	3.99
	SD	575.83	38.75	4.72	3.55	2.10	3.32	6.07	0.99	0.39
	SS
112	Mean	12500.9	410.71	92.29	38.18	27.03	15.66	33.91	5.17	3.98
	SD	979.47	81.72	8.77	4.43	4.97	4.22	7.88	1.16	0.65
	SS
150	Mean	12877.3	434.48	90.82	39.24	25.47	12.98	30.44	6.20	3.91
	SD	987.87	51.27	6.19	2.98	3.65	1.95	4.90	1.09	0.50
	SS
187	Mean	12704.5	457.84	93.31	38.90	25.31	15.52	32.06	6.39	3.78
	SD	663.31	50.35	5.06	3.02	2.47	4.10	6.48	1.57	0.51
	SS
225	Mean	12648.4	481.25	93.02	38.73	24.04	12.23	28.71	6.90	3.66
	SD	894.76	60.74	9.13	2.63	2.32	1.99	5.83	1.42	0.56
	SS
Test for significance		NS		DN	NS	NS	DN	NS	DN	NS
Historical control range		10000.0–13686.6	263.82–408.74	66.67–125.81	30.29–44.09	17.11–28.87	8.96–21.86	20.85–51.63	3.49–7.00	2.99–5.56
Recovery groups
Male								Testes	Epididymides
0 (Control)	Mean	20125.0	467.52	111.63	50.50	30.20	15.00	154.83	71.65	2.79
	SD	1271.17	35.97	11.76	3.41	1.85	3.21	9.87	4.90	0.30
225	Mean	18964.2	460.18	119.63	52.16	38.20	21.44	114.56	59.61	2.84
	SD	1517.80	43.82	8.62	5.60	2.96	1.57	46.71	5.88	0.45
	SS
Test for significance		NS	NS	NS	NS			NS		NS
Female								Ovaries	Uterus
0 (Control)	Mean	11754.7	288.38	74.77	35.70	22.71	12.19	30.08	4.40	3.40
	SD	851.77	23.84	12.02	4.25	1.70	3.26	6.83	0.53	0.22
225	Mean	12010.5	342.70	82.02	38.43	24.95	18.16	38.57	4.94	3.83
	SD	731.38	41.11	6.49	1.42	3.32	3.03	5.94	0.68	0.55
	SS
Test for significance		NS		NS	NS	NS		NS	NS	NS

Abbreviations: DN, Duncan’s multiple range test; NS, not significant; SD, standard deviation; SS, statistically significant compared to control; -test versus control; , Mann-Whitney -test versus control.Remarks: Paired organs were weighed together..